LARS2

From Wikipedia, the free encyclopedia

Leucyl-tRNA synthetase 2, mitochondrial

Identifiers

LARS2; KIAA0028; LEURS; MGC26121

External IDs

OMIM: 604544 MGI: 2142973 HomoloGene: 6526

Gene ontology
Molecular Function:	• nucleotide binding • leucine-tRNA ligase activity • ATP binding • ligase activity
Cellular Component:	• mitochondrion
Biological Process:	• leucyl-tRNA aminoacylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015340 (mRNA)
NP_056155 (protein)

NM_153168 (mRNA)
NP_694808 (protein)

Location

Chr 3: 45.41 - 45.57 Mb

Chr 9: 123.22 - 123.31 Mb

Pubmed search

[1]

[2]

Leucyl-tRNA synthetase 2, mitochondrial, also known as LARS2, is a human gene.^[1]

This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid.^[1]

[edit] References

^ ^a ^b Entrez Gene: LARS2 leucyl-tRNA synthetase 2, mitochondrial.

[edit] Further reading

Olsson P, Wennberg AL (1992). "[Midwife and research. Conference report]". Jordemodern 104 (11): 408-9, 404. PMID 1684970.
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.". DNA Res. 1 (1): 27-35. PMID 7584026.
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).". DNA Res. 1 (1): 47-56. PMID 7584028.
Szeles A, Yang Y, Sandlund AM, et al. (1998). "Human/mouse microcell hybrid based elimination test reduces the putative tumor suppressor region at 3p21.3 to 1.6 cM.". Genes Chromosomes Cancer 20 (4): 329-36. PMID 9408748.
Kiss H, Kedra D, Yang Y, et al. (2000). "A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3.". Hum. Genet. 105 (6): 552-9. PMID 10647888.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Yao YN, Wang L, Wu XF, Wang ED (2004). "The processing of human mitochondrial leucyl-tRNA synthetase in the insect cells.". FEBS Lett. 534 (1-3): 139-42. PMID 12527375.
Park H, Davidson E, King MP (2003). "The pathogenic A3243G mutation in human mitochondrial tRNALeu(UUR) decreases the efficiency of aminoacylation.". Biochemistry 42 (4): 958-64. doi:10.1021/bi026882r. PMID 12549915.
Yao YN, Wang L, Wu XF, Wang ED (2004). "Human mitochondrial leucyl-tRNA synthetase with high activity produced from Escherichia coli.". Protein Expr. Purif. 30 (1): 112-6. PMID 12821328.
Sohm B, Sissler M, Park H, et al. (2004). "Recognition of human mitochondrial tRNALeu(UUR) by its cognate leucyl-tRNA synthetase.". J. Mol. Biol. 339 (1): 17-29. doi:10.1016/j.jmb.2004.03.066. PMID 15123417.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Munakata K, Iwamoto K, Bundo M, Kato T (2005). "Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia.". Biol. Psychiatry 57 (5): 525-32. doi:10.1016/j.biopsych.2004.11.041. PMID 15737668.
't Hart LM, Hansen T, Rietveld I, et al. (2005). "Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene.". Diabetes 54 (6): 1892-5. PMID 15919814.