Lactosylceramide beta-1,3-galactosyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a lactosylceramide beta-1,3-galactosyltransferase (EC 2.4.1.179) is an enzyme that catalyzes the chemical reaction

UDP-galactose + D-galactosyl-1,4-beta-D-glucosyl-R UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R

Thus, the two substrates of this enzyme are UDP-galactose and D-galactosyl-1,4-beta-D-glucosyl-R, whereas its two products are UDP and D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase. Other names in common use include uridine diphosphogalactose-lactosylceramide, and beta1->3-galactosyltransferase.

[edit] References

• IUBMB entry for 2.4.1.179
• BRENDA references for 2.4.1.179 (Recommended.)
• PubMed references for 2.4.1.179
• PubMed Central references for 2.4.1.179
• Google Scholar references for 2.4.1.179
• Bailly P, Piller F, Cartron JP (1988). "Characterization and specific assay for a galactoside beta-3-galactosyltransferase of human kidney". Eur. J. Biochem. 173: 417–22. doi:10.1111/j.1432-1033.1988.tb14015.x. PMID 3129295. 

[edit] External links

The CAS registry number for this enzyme class is 106769-64-6.

• IUBMB entry for 2.4.1.179

• KEGG entry for 2.4.1.179

• BRENDA entry for 2.4.1.179

• NiceZyme view of 2.4.1.179

• EC2PDB: PDB structures for 2.4.1.179

• PRIAM entry for 2.4.1.179

• PUMA2 entry for 2.4.1.179

• IntEnz: Integrated Enzyme entry for 2.4.1.179

• MetaCyc entry for 2.4.1.179

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047240: lactosylceramide beta-1,3-galactosyltransferase

• AMIGO entry for GO code 0047240: lactosylceramide beta-1,3-galactosyltransferase