Lactosylceramide alpha-2,6-N-sialyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a lactosylceramide alpha-2,6-N-sialyltransferase (EC 2.4.99.11) is an enzyme that catalyzes the chemical reaction

CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide $\rightleftharpoons$ CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D- glucosylceramide

Thus, the two substrates of this enzyme are CMP-N-acetylneuraminate and beta-D-galactosyl-1,4-beta-D-glucosylceramide, whereas its 3 products are CMP, alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D-, and glucosylceramide.

This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:lactosylceramide alpha-2,6-N-acetylneuraminyltransferase. Other names in common use include cytidine monophosphoacetylneuraminate-lactosylceramide, sialyltransferase, CMP-acetylneuraminate-lactosylceramide-sialyltransferase, CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase, CMP-sialic acid:lactosylceramide sialyltransferase, cytidine monophosphoacetylneuraminate-lactosylceramide, and sialyltransferase.

[edit] References

IUBMB entry for 2.4.99.11
BRENDA references for 2.4.99.11 (Recommended.)
PubMed references for 2.4.99.11
PubMed Central references for 2.4.99.11
Google Scholar references for 2.4.99.11
Albarracin I, Lassaga FE, Caputto R (1988). "Purification and characterization of an endogenous inhibitor of the sialyltransferase CMP-N-acetylneuraminate: lactosylceramide alpha 2,6-N-acetylneuraminyltransferase (EC 2.4.99.-)". Biochem. J. 254: 559–65. PMID 2460092.
Landa CA, Maccioni HJ, Arce A, Caputto R (1977). "The biosynthesis of brain gangliosides. Separation of membranes with different ratios of ganglioside sialylating activity to gangliosides". Biochem. J. 168: 325–32. PMID 606237.