LACTB

From Wikipedia, the free encyclopedia

Lactamase, beta

Identifiers

LACTB; FLJ14902; G24; MRPL56

External IDs

OMIM: 608440 MGI: 1933395 HomoloGene: 12755

Gene ontology
Molecular Function:	• beta-lactamase activity • hydrolase activity
Cellular Component:	• mitochondrion
Biological Process:	• beta-lactam antibiotic catabolic process • response to antibiotic

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_032857 (mRNA)
NP_116246 (protein)

NM_030717 (mRNA)
NP_109642 (protein)

Location

Chr 15: 61.2 - 61.22 Mb

n/a

Pubmed search

[1]

[2]

Lactamase, beta, also known as LACTB, is a human gene.^[1]

This gene encodes a protein from the large 39S subunit of the mitochondrial ribosome (mitoribosome). The encoded protein has some sequence similarity to prokaryotic beta-lactamases but most of the residues that are responsible for the beta-lactamase activity are not conserved between the two proteins.^[1]

[edit] References

^ ^a ^b Entrez Gene: LACTB lactamase, beta.

[edit] Further reading

Hallis TM, Kopp AL, Gibson J, et al. (2007). "An improved beta-lactamase reporter assay: multiplexing with a cytotoxicity readout for enhanced accuracy of hit identification.". Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 12 (5): 635–44. doi:10.1177/1087057107301499. PMID 17517902.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hell-Pourmojib M, Neuner P, Fischer H, et al. (2002). "Differential expression of a novel gene in response to hsp27 and cell differentiation in human keratinocytes.". J. Invest. Dermatol. 119 (1): 154–9. doi:10.1046/j.1523-1747.2002.01793.x. PMID 12164938.
Smith TS, Southan C, Ellington K, et al. (2002). "Identification, genomic organization, and mRNA expression of LACTB, encoding a serine beta-lactamase-like protein with an amino-terminal transmembrane domain.". Genomics 78 (1-2): 12–4. doi:10.1006/geno.2001.6643. PMID 11707067.
Koc EC, Burkhart W, Blackburn K, et al. (2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.". J. Biol. Chem. 276 (47): 43958–69. doi:10.1074/jbc.M106510200. PMID 11551941.