L-galactonolactone oxidase

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In enzymology, a L-galactonolactone oxidase (EC 1.3.3.12) is an enzyme that catalyzes the chemical reaction

L-galactono-1,4-lactone + O₂ L-ascorbate + H₂O₂

Thus, the two substrates of this enzyme are L-galactono-1,4-lactone and O₂, whereas its two products are L-ascorbic acid and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is L-galactono-1,4-lactone:oxygen 3-oxidoreductase. This enzyme is also called L-galactono-1,4-lactone oxidase. This enzyme participates in ascorbic acid and aldaric acid metabolism. It employs one cofactor, FAD.

[edit] References

• IUBMB entry for 1.3.3.12
• BRENDA references for 1.3.3.12 (Recommended.)
• PubMed references for 1.3.3.12
• PubMed Central references for 1.3.3.12
• Google Scholar references for 1.3.3.12
• Bleeg HS, Christensen F (1982). "Biosynthesis of ascorbate in yeast. Purification of L-galactono-1,4-lactone oxidase with properties different from mammalian L-gulonolactone oxidase". Eur. J. Biochem. 127: 391–6. doi:10.1111/j.1432-1033.1982.tb06884.x. PMID 6754380. 

[edit] External links

The CAS registry number for this enzyme class is 69403-13-0.

• IUBMB entry for 1.3.3.12

• KEGG entry for 1.3.3.12

• BRENDA entry for 1.3.3.12

• NiceZyme view of 1.3.3.12

• EC2PDB: PDB structures for 1.3.3.12

• PRIAM entry for 1.3.3.12

• PUMA2 entry for 1.3.3.12

• IntEnz: Integrated Enzyme entry for 1.3.3.12

• MetaCyc entry for 1.3.3.12

• Atomic-resolution structures of enzymes belonging to this class