L-3-cyanoalanine synthase

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In enzymology, a L-3-cyanoalanine synthase (EC 4.4.1.9) is an enzyme that catalyzes the chemical reaction

L-cysteine + hydrogen cyanide $\rightleftharpoons$ L-3-cyanoalanine + hydrogen sulfide

Thus, the two substrates of this enzyme are L-cysteine and hydrogen cyanide, whereas its two products are L-3-cyanoalanine and hydrogen sulfide.

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide L-3-cyanoalanine-forming). Other names in common use include beta-cyanoalanine synthase, beta-cyanoalanine synthetase, beta-cyano-L-alanine synthase, and L-cysteine hydrogen-sulfide-lyase (adding HCN). This enzyme participates in cyanoamino acid metabolism.

[edit] References

IUBMB entry for 4.4.1.9
BRENDA references for 4.4.1.9 (Recommended.)
PubMed references for 4.4.1.9
PubMed Central references for 4.4.1.9
Google Scholar references for 4.4.1.9
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Castric PA, Conn EE (1971). "Formation of -cyanoalanine by O-acetylserine sulfhydrylase". J. Bacteriol. 108: 132–6. PMID 5001194.
Hendrickson HR (1968). "The beta-cyanoalanine synthase of blue lupine". Fed. Proc. 27: 593.
Hendrickson HR, Conn EE (1969). "Cyanide metabolism in higher plants. IV. Purification and properties of the beta-cyanolanine synthase of blue lupine". J. Biol. Chem. 244: 2632–40. PMID 5769995.