Kynurenine 7,8-hydroxylase

From Wikipedia, the free encyclopedia

In enzymology, a kynurenine 7,8-hydroxylase (EC 1.14.99.2) is an enzyme that catalyzes the chemical reaction

kynurenate + AH₂ + O₂ 7,8-dihydro-7,8-dihydroxykynurenate + A

The 3 substrates of this enzyme are kynurenate, AH2, and O₂, whereas its two products are 7,8-dihydro-7,8-dihydroxykynurenate and A.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating). Other names in common use include kynurenic acid hydroxylase, kynurenic hydroxylase, and kynurenate 7,8-hydroxylase. This enzyme participates in tryptophan metabolism.

[edit] References

• IUBMB entry for 1.14.99.2
• BRENDA references for 1.14.99.2 (Recommended.)
• PubMed references for 1.14.99.2
• PubMed Central references for 1.14.99.2
• Google Scholar references for 1.14.99.2
• Taniuchi H and Hayaishi O (1963). "Studies on the metabolism of kynurenic acid. III. Enzymatic formation of 7,8-dihydroxykynurenic acid from kynurenic acid". J. Biol. Chem. 238: 283–293. 

[edit] External links

The CAS registry number for this enzyme class is 9029-63-4.

• IUBMB entry for 1.14.99.2

• KEGG entry for 1.14.99.2

• BRENDA entry for 1.14.99.2

• NiceZyme view of 1.14.99.2

• EC2PDB: PDB structures for 1.14.99.2

• PRIAM entry for 1.14.99.2

• PUMA2 entry for 1.14.99.2

• IntEnz: Integrated Enzyme entry for 1.14.99.2

• MetaCyc entry for 1.14.99.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050016: kynurenine 7,8-hydroxylase

• AMIGO entry for GO code 0050016: kynurenine 7,8-hydroxylase