Kua-UEV

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Ubiquitin-conjugating enzyme E2 variant 1
PDB rendering based on 1j74.
Available structures: 1j74, 1j7d, 1zgu, 2a4d, 2c2v, 2hlw
Identifiers
Symbol(s) Kua-UEV; UBE2V1; CROC-1B
External IDs HomoloGene: 76465
Orthologs
Human Mouse
Entrez 387522 n/a


Refseq NM_003349 (mRNA)
NP_003340 (protein)		 n/a (mRNA)
n/a (protein)
Pubmed search [1] n/a

Ubiquitin-conjugating enzyme E2 variant 1, also known as Kua-UEV, is a human gene.[1]

The Kua-UEV mRNA is an infrequent but naturally occurring co-transcribed product of the neighboring Kua and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. Two alternative transcripts encoding different isoforms have been described. The proteins produced by these transcripts have UEV1 B domains but the proteins are localized to the cytoplasm rather than to the nucleus. The significance of these co-transcribed mRNAs and the function of their protein products have not yet been determined.[1]

[edit] References

  1. ^ a b Entrez Gene: Kua-UEV ubiquitin-conjugating enzyme E2 variant 1.

[edit] Further reading

  • Long M (2001). "A new function evolved from gene fusion.". Genome Res. 10 (11): 1655–7. PMID 11076848. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. 
  • Rothofsky ML, Lin SL (1997). "CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter.". Gene 195 (2): 141–9. PMID 9305758. 
  • Sancho E, Vilá MR, Sánchez-Pulido L, et al. (1998). "Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells.". Mol. Cell. Biol. 18 (1): 576–89. PMID 9418904. 
  • Xiao W, Lin SL, Broomfield S, et al. (1998). "The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family.". Nucleic Acids Res. 26 (17): 3908–14. PMID 9705497. 
  • Ma L, Broomfield S, Lavery C, et al. (1998). "Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines.". Oncogene 17 (10): 1321–6. doi:10.1038/sj.onc.1202058. PMID 9771976. 
  • Hofmann RM, Pickart CM (1999). "Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair.". Cell 96 (5): 645–53. PMID 10089880. 
  • Deng L, Wang C, Spencer E, et al. (2000). "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain.". Cell 103 (2): 351–61. PMID 11057907. 
  • Thomson TM, Lozano JJ, Loukili N, et al. (2001). "Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene.". Genome Res. 10 (11): 1743–56. PMID 11076860. 
  • Dias DC, Dolios G, Wang R, Pan ZQ (2003). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16601–6. doi:10.1073/pnas.252646399. PMID 12481031. 
  • Guo D, Han J, Adam BL, et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267. 
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