KRT78

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Keratin 78
Identifiers
Symbol(s) KRT78; K5B
External IDs MGI: 1917529 HomoloGene: 65261
Orthologs
Human Mouse
Entrez 196374 332131
Ensembl ENSG00000170423 n/a
Refseq NM_173352 (mRNA)
NP_775487 (protein)		 XM_993221 (mRNA)
XP_998315 (protein)
Location Chr 12: 51.52 - 51.53 Mb n/a
Pubmed search [1] [2]

Keratin 78, also known as KRT78, is a human gene.[1]

This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified.[1]

[edit] References

  1. ^ a b Entrez Gene: KRT78 keratin 78.

[edit] Further reading

  • Coulombe PA, Omary MB (2002). "'Hard' and 'soft' principles defining the structure, function and regulation of keratin intermediate filaments.". Curr. Opin. Cell Biol. 14 (1): 110-22. PMID 11792552. 
  • Mischke D, Wild G (1987). "Polymorphic keratins in human epidermis.". J. Invest. Dermatol. 88 (2): 191-7. PMID 2433356. 
  • Rogers MA, Winter H, Langbein L, et al. (2000). "Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain.". J. Invest. Dermatol. 114 (3): 464-72. doi:10.1046/j.1523-1747.2000.00910.x. PMID 10692104. 
  • Hesse M, Magin TM, Weber K (2002). "Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18.". J. Cell. Sci. 114 (Pt 14): 2569-75. PMID 11683385. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Hesse M, Zimek A, Weber K, Magin TM (2004). "Comprehensive analysis of keratin gene clusters in humans and rodents.". Eur. J. Cell Biol. 83 (1): 19-26. PMID 15085952. 
  • Rogers MA, Edler L, Winter H, et al. (2005). "Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13.". J. Invest. Dermatol. 124 (3): 536-44. doi:10.1111/j.0022-202X.2004.23530.x. PMID 15737194. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Schweizer J, Bowden PE, Coulombe PA, et al. (2006). "New consensus nomenclature for mammalian keratins.". J. Cell Biol. 174 (2): 169-74. doi:10.1083/jcb.200603161. PMID 16831889. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
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