KRT34

From Wikipedia, the free encyclopedia

Keratin 34

Identifiers

KRT34; HA4; Ha-4; KRTHA4; hHa4

External IDs

OMIM: 602763 MGI: 1309994 HomoloGene: 31083

Gene ontology
Molecular Function:	• structural molecule activity
Cellular Component:	• intermediate filament
Biological Process:	• epidermis development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_021013 (mRNA)
NP_066293 (protein)

NM_027563 (mRNA)
NP_081839 (protein)

Location

Chr 17: 36.79 - 36.79 Mb

Chr 11: 99.85 - 99.86 Mb

Pubmed search

[1]

[2]

Keratin 34, also known as KRT34, is a human gene.^[1]

The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription.^[1]

[edit] References

^ ^a ^b Entrez Gene: KRT34 keratin 34.

[edit] Further reading

Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins.". J. Invest. Dermatol. 101 (1 Suppl): 56S-59S. PMID 7686952.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Schweizer J, Bowden PE, Coulombe PA, et al. (2006). "New consensus nomenclature for mammalian keratins.". J. Cell Biol. 174 (2): 169-74. doi:10.1083/jcb.200603161. PMID 16831889.
Raica M, Zylis D, Cîmpean AM (2007). "Cytokeratin 20, 34betaE12 and overexpression of HER-2/neu in urine cytology as predictors of recurrences in superficial urothelial carcinoma.". Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie 46 (1): 11-5. PMID 16286979.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle.". J. Biol. Chem. 274 (28): 19874-84. PMID 10391933.
Rogers MA, Winter H, Wolf C, et al. (1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes.". J. Biol. Chem. 273 (41): 26683-91. PMID 9756910.
Heid HW, Werner E, Franke WW (1987). "The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins.". Differentiation 32 (2): 101-19. PMID 2431943.