KRT31

From Wikipedia, the free encyclopedia

Keratin 31

Identifiers

KRT31; HA1; Ha-1; KRTHA1; MGC138630; hHa1

External IDs

OMIM: 601077 MGI: 1309993 HomoloGene: 74433

Gene ontology
Molecular Function:	• structural constituent of cytoskeleton
Cellular Component:	• intermediate filament
Biological Process:	• epidermis development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002277 (mRNA)
NP_002268 (protein)

NM_010659 (mRNA)
NP_034789 (protein)

Location

Chr 17: 36.8 - 36.81 Mb

Chr 11: 99.86 - 99.87 Mb

Pubmed search

[1]

[2]

Keratin 31, also known as KRT31, is a human gene.^[1]

The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription.^[1]

[edit] References

^ ^a ^b Entrez Gene: KRT31 keratin 31.

[edit] Further reading

Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins.". J. Invest. Dermatol. 101 (1 Suppl): 56S–59S. PMID 7686952.
Dhouailly D, Xu C, Manabe M, et al. (1989). "Expression of hair-related keratins in a soft epithelium: subpopulations of human and mouse dorsal tongue keratinocytes express keratin markers for hair-, skin- and esophageal-types of differentiation.". Exp. Cell Res. 181 (1): 141–58. PMID 2465162.
Bowden PE, Hainey S, Parker G, Hodgins MB (1995). "Sequence and expression of human hair keratin genes.". J. Dermatol. Sci. 7 Suppl: S152–63. PMID 7528047.
Fink P, Rogers MA, Korge B, et al. (1995). "A cDNA encoding the human type I hair keratin hHal.". Biochim. Biophys. Acta 1264 (1): 12–4. PMID 7578244.
Winter H, Hofmann I, Langbein L, et al. (1998). "A splice site mutation in the gene of the human type I hair keratin hHa1 results in the expression of a tailless keratin isoform.". J. Biol. Chem. 272 (51): 32345–52. PMID 9405442.
Bowden PE, Hainey SD, Parker G, et al. (1998). "Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle.". J. Invest. Dermatol. 110 (2): 158–64. doi:10.1046/j.1523-1747.1998.00097.x. PMID 9457912.
Rogers MA, Winter H, Wolf C, et al. (1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes.". J. Biol. Chem. 273 (41): 26683–91. PMID 9756910.
Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle.". J. Biol. Chem. 274 (28): 19874–84. PMID 10391933.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Cribier B, Peltre B, Grosshans E, et al. (2004). "On the regulation of hair keratin expression: lessons from studies in pilomatricomas.". J. Invest. Dermatol. 122 (5): 1078–83. doi:10.1111/j.0022-202X.2004.22513.x. PMID 15140206.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Schweizer J, Bowden PE, Coulombe PA, et al. (2006). "New consensus nomenclature for mammalian keratins.". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMID 16831889.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.