Krapcho decarboxylation

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The Krapcho decarboxylation is the chemical reaction of esters with halide anions. The ester must contain an electron-withdrawing group in the beta position, such as β-ketoesters, malonic esters, α-cyanoesters, or α-sulfonylesters.[1][2]

[edit] References

  1. ^ Krapcho, A. P.; Glynn, G. A.; Grenon, B. J. Tetrahedron Lett. 1967, 8, 215.
  2. ^ Flynn, D. L.; Becker, D. P.; Nosal, R.; Zabrowski, D. L. Tetrahedron Lett. 1992, 33, 7283.


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