Krüppel

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Krüppel is a gap gene which encodes a zinc finger protein with four tandemly repeated zinc finger domains.[1]

Krüppel means, literally, "cripple" in German.

Put into English, it controls the development of a zygote early on in its growth, causing a gap in the otherwise heterogeneous arrangement of cells. It also controls access to several other subsequent genes, imposing order on the developing embryo.[2]

See also Kruppel-like factors which have been recently investigated in the heart but are well characterised for their role in carcinogenesis.

[edit] External links

  • Diagram at Davidson College - a Drosophila embryo at the cellular blastoderm stage triple-labeled for three segmentation proteins including Krüppel (in blue) Hairy (green) and Giant (red).

[edit] References

  1. ^ Online 'Mendelian Inheritance in Man' (OMIM) 165220
  2. ^ Interactive Fly, Drosophila

[edit] External links


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