KLRC4

From Wikipedia, the free encyclopedia

Killer cell lectin-like receptor subfamily C, member 4

Identifiers

KLRC4; NKG2-F; NKG2F

External IDs

Gene ontology
Molecular Function:	• receptor activity • protein binding • sugar binding • natural killer cell receptor activity
Cellular Component:	• integral to plasma membrane • membrane • integral to membrane
Biological Process:	• cellular defense response • signal transduction • antimicrobial humoral response

Orthologs

Human

Mouse

Entrez

8302

n/a

Refseq

NM_013431 (mRNA)
NP_038459 (protein)

n/a (mRNA)
n/a (protein)

Pubmed search

[1]

n/a

Killer cell lectin-like receptor subfamily C, member 4, also known as KLRC4, is a human gene.^[1]

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC4 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. The 3' end of the KLRC4 transcript includes the first non-coding exon found at the 5' end of the adjacent D12S2489E gene transcript.^[1]

[edit] References

^ ^a ^b Entrez Gene: KLRC4 killer cell lectin-like receptor subfamily C, member 4.

[edit] Further reading

Vivier E, Tomasello E, Paul P (2002). "Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition?". Curr. Opin. Immunol. 14 (3): 306-11. PMID 11973127.
Houchins JP, Yabe T, McSherry C, Bach FH (1991). "DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells.". J. Exp. Med. 173 (4): 1017-20. PMID 2007850.
Yabe T, McSherry C, Bach FH, et al. (1993). "A multigene family on human chromosome 12 encodes natural killer-cell lectins.". Immunogenetics 37 (6): 455-60. PMID 8436421.
Plougastel B, Trowsdale J (1998). "Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes.". Eur. J. Immunol. 27 (11): 2835-9. PMID 9394807.
Plougastel B, Trowsdale J (1998). "Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes.". Genomics 49 (2): 193-9. doi:10.1006/geno.1997.5197. PMID 9598306.
Glienke J, Sobanov Y, Brostjan C, et al. (1998). "The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex.". Immunogenetics 48 (3): 163-73. PMID 9683661.
Bauer S, Groh V, Wu J, et al. (1999). "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.". Science 285 (5428): 727-9. PMID 10426993.
Wu J, Song Y, Bakker AB, et al. (1999). "An activating immunoreceptor complex formed by NKG2D and DAP10.". Science 285 (5428): 730-2. PMID 10426994.
Li P, Morris DL, Willcox BE, et al. (2001). "Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA.". Nat. Immunol. 2 (5): 443-51. doi:10.1038/87757. PMID 11323699.
O'Callaghan CA, Cerwenka A, Willcox BE, et al. (2001). "Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60.". Immunity 15 (2): 201-11. PMID 11520456.
Girardi M, Oppenheim DE, Steele CR, et al. (2001). "Regulation of cutaneous malignancy by gammadelta T cells.". Science 294 (5542): 605-9. doi:10.1126/science.1063916. PMID 11567106.
Shum BP, Flodin LR, Muir DG, et al. (2002). "Conservation and variation in human and common chimpanzee CD94 and NKG2 genes.". J. Immunol. 168 (1): 240-52. PMID 11751968.
Radaev S, Rostro B, Brooks AG, et al. (2002). "Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3.". Immunity 15 (6): 1039-49. PMID 11754823.
Sutherland CL, Chalupny NJ, Schooley K, et al. (2002). "UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells.". J. Immunol. 168 (2): 671-9. PMID 11777960.
Holmes MA, Li P, Petersdorf EW, Strong RK (2002). "Structural studies of allelic diversity of the MHC class I homolog MIC-B, a stress-inducible ligand for the activating immunoreceptor NKG2D.". J. Immunol. 169 (3): 1395-400. PMID 12133964.
Gilfillan S, Ho EL, Cella M, et al. (2002). "NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation.". Nat. Immunol. 3 (12): 1150-5. doi:10.1038/ni857. PMID 12426564.
Diefenbach A, Tomasello E, Lucas M, et al. (2002). "Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D.". Nat. Immunol. 3 (12): 1142-9. doi:10.1038/ni858. PMID 12426565.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
McFarland BJ, Kortemme T, Yu SF, et al. (2004). "Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands.". Structure 11 (4): 411-22. PMID 12679019.