KIF5B

From Wikipedia, the free encyclopedia

Kinesin family member 5B

PDB rendering based on 1bg2.

Available structures: 1bg2, 1mkj

Identifiers

Symbol(s)

KIF5B; KINH; KNS; KNS1; UKHC

External IDs

OMIM: 602809 MGI: 1098268 HomoloGene: 55829

Gene ontology
Molecular Function:	• nucleotide binding • microtubule motor activity • protein binding • ATP binding
Cellular Component:	• cytoplasm • kinesin complex • microtubule • ciliary rootlet • neuron projection
Biological Process:	• microtubule-based movement • cytoplasm organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004521 (mRNA)
NP_004512 (protein)

NM_008448 (mRNA)
NP_032474 (protein)

Location

Chr 10: 32.34 - 32.39 Mb

Chr 18: 6.2 - 6.24 Mb

Pubmed search

[1]

[2]

Kinesin family member 5B, also known as KIF5B, is a human gene.^[1]

[edit] References

^ Entrez Gene: KIF5B kinesin family member 5B.

[edit] Further reading

Navone F, Niclas J, Hom-Booher N, et al. (1992). "Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells.". J. Cell Biol. 117 (6): 1263-75. PMID 1607388.
Niclas J, Navone F, Hom-Booher N, Vale RD (1994). "Cloning and localization of a conventional kinesin motor expressed exclusively in neurons.". Neuron 12 (5): 1059-72. PMID 7514426.
Kull FJ, Sablin EP, Lau R, et al. (1996). "Crystal structure of the kinesin motor domain reveals a structural similarity to myosin.". Nature 380 (6574): 550-5. doi:10.1038/380550a0. PMID 8606779.
Rahman A, Friedman DS, Goldstein LS (1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins.". J. Biol. Chem. 273 (25): 15395-403. PMID 9624122.
Tanaka Y, Kanai Y, Okada Y, et al. (1998). "Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria.". Cell 93 (7): 1147-58. PMID 9657148.
Rahman A, Kamal A, Roberts EA, Goldstein LS (1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants.". J. Cell Biol. 146 (6): 1277-88. PMID 10491391.
Ong LL, Lim AP, Er CP, et al. (2000). "Kinectin-kinesin binding domains and their effects on organelle motility.". J. Biol. Chem. 275 (42): 32854-60. doi:10.1074/jbc.M005650200. PMID 10913441.
Kanai Y, Okada Y, Tanaka Y, et al. (2000). "KIF5C, a novel neuronal kinesin enriched in motor neurons.". J. Neurosci. 20 (17): 6374-84. PMID 10964943.
Setou M, Seog DH, Tanaka Y, et al. (2002). "Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites.". Nature 417 (6884): 83-7. doi:10.1038/nature743. PMID 11986669.
Hakimi MA, Speicher DW, Shiekhattar R (2002). "The motor protein kinesin-1 links neurofibromin and merlin in a common cellular pathway of neurofibromatosis.". J. Biol. Chem. 277 (40): 36909-12. doi:10.1074/jbc.C200434200. PMID 12191989.
Diefenbach RJ, Diefenbach E, Douglas MW, Cunningham AL (2003). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23.". Biochemistry 41 (50): 14906-15. PMID 12475239.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Macioce P, Gambara G, Bernassola M, et al. (2004). "Beta-dystrobrevin interacts directly with kinesin heavy chain in brain.". J. Cell. Sci. 116 (Pt 23): 4847-56. doi:10.1242/jcs.00805. PMID 14600269.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054.
Diefenbach RJ, Diefenbach E, Douglas MW, Cunningham AL (2004). "The ribosome receptor, p180, interacts with kinesin heavy chain, KIF5B.". Biochem. Biophys. Res. Commun. 319 (3): 987-92. doi:10.1016/j.bbrc.2004.05.069. PMID 15184079.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436-50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Su Q, Cai Q, Gerwin C, et al. (2004). "Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons.". Nat. Cell Biol. 6 (10): 941-53. doi:10.1038/ncb1169. PMID 15459722.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Brickley K, Smith MJ, Beck M, Stephenson FA (2005). "GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin.". J. Biol. Chem. 280 (15): 14723-32. doi:10.1074/jbc.M409095200. PMID 15644324.
Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.". Mol. Cell Proteomics 4 (6): 785-95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.