KIF2C

From Wikipedia, the free encyclopedia

Kinesin family member 2C

PDB rendering based on 1v8j.

Available structures: 1v8j, 1v8k, 2heh

Identifiers

Symbol(s)

KIF2C; KNSL6; MCAK

External IDs

OMIM: 604538 MGI: 1921054 HomoloGene: 21355

Gene ontology
Molecular Function:	• nucleotide binding • microtubule motor activity • protein binding • ATP binding • centromeric DNA binding
Cellular Component:	• chromosome, pericentric region • nucleus • kinesin complex • microtubule
Biological Process:	• microtubule-based movement • mitosis • cell proliferation • establishment and/or maintenance of microtubule cytoskeleton polarity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006845 (mRNA)
NP_006836 (protein)

XM_986203 (mRNA)
XP_991297 (protein)

Location

Chr 1: 44.98 - 45.01 Mb

Chr 4: 116.66 - 116.68 Mb

Pubmed search

[1]

[2]

Kinesin family member 2C, also known as KIF2C, is a human gene.^[1]

The protein encoded by this gene is a member of kinesin-like protein family. Most proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein acts to regulate microtubule dynamics in cells and is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation.^[1]

[edit] References

^ ^a ^b Entrez Gene: KIF2C kinesin family member 2C.

[edit] Further reading

Miki H, Setou M, Kaneshiro K, Hirokawa N (2001). "All kinesin superfamily protein, KIF, genes in mouse and human.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7004-11. doi:10.1073/pnas.111145398. PMID 11416179.
Kim IG, Jun DY, Sohn U, Kim YH (1998). "Cloning and expression of human mitotic centromere-associated kinesin gene.". Biochim. Biophys. Acta 1359 (3): 181-6. PMID 9434124.
Maney T, Hunter AW, Wagenbach M, Wordeman L (1998). "Mitotic centromere-associated kinesin is important for anaphase chromosome segregation.". J. Cell Biol. 142 (3): 787-801. PMID 9700166.
Wordeman L, Wagenbach M, Maney T (2000). "Mutations in the ATP-binding domain affect the subcellular distribution of mitotic centromere-associated kinesin (MCAK).". Cell Biol. Int. 23 (4): 275-86. doi:10.1006/cbir.1999.0359. PMID 10600236.
Sugata N, Li S, Earnshaw WC, et al. (2001). "Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes.". Hum. Mol. Genet. 9 (19): 2919-26. PMID 11092768.
Maney T, Wagenbach M, Wordeman L (2001). "Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesin.". J. Biol. Chem. 276 (37): 34753-8. doi:10.1074/jbc.M106626200. PMID 11466324.
Cheng LJ, Zhou ZM, Li JM, et al. (2002). "Expression of a novel HsMCAK mRNA splice variant, tsMCAK gene, in human testis.". Life Sci. 71 (23): 2741-57. PMID 12383881.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Cassimeris L, Morabito J (2004). "TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly.". Mol. Biol. Cell 15 (4): 1580-90. doi:10.1091/mbc.E03-07-0544. PMID 14718566.
Ganem NJ, Compton DA (2004). "The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK.". J. Cell Biol. 166 (4): 473-8. doi:10.1083/jcb.200404012. PMID 15302853.
Newton CN, Wagenbach M, Ovechkina Y, et al. (2004). "MCAK, a Kin I kinesin, increases the catastrophe frequency of steady-state HeLa cell microtubules in an ATP-dependent manner in vitro.". FEBS Lett. 572 (1-3): 80-4. doi:10.1016/j.febslet.2004.06.093. PMID 15304328.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77-83. doi:10.1038/nature03207. PMID 15635413.
Moore AT, Rankin KE, von Dassow G, et al. (2005). "MCAK associates with the tips of polymerizing microtubules.". J. Cell Biol. 169 (3): 391-7. doi:10.1083/jcb.200411089. PMID 15883193.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Ganem NJ, Upton K, Compton DA (2006). "Efficient mitosis in human cells lacking poleward microtubule flux.". Curr. Biol. 15 (20): 1827-32. doi:10.1016/j.cub.2005.08.065. PMID 16243029.
Helenius J, Brouhard G, Kalaidzidis Y, et al. (2006). "The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends.". Nature 441 (7089): 115-9. doi:10.1038/nature04736. PMID 16672973.
Sun Y, Huang YC, Xu QZ, et al. (2006). "HIV-1 Tat depresses DNA-PK(CS) expression and DNA repair, and sensitizes cells to ionizing radiation.". Int. J. Radiat. Oncol. Biol. Phys. 65 (3): 842-50. doi:10.1016/j.ijrobp.2006.02.040. PMID 16751065.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.