KIF2A

From Wikipedia, the free encyclopedia

Kinesin heavy chain member 2A

PDB rendering based on 2gry.

Available structures: 2gry

Identifiers

Symbol(s)

KIF2A; HK2; KIF2

External IDs

OMIM: 602591 MGI: 108390 HomoloGene: 3320

Gene ontology
Molecular Function:	• nucleotide binding • microtubule motor activity • ATP binding
Cellular Component:	• cytoskeleton • microtubule • microtubule associated complex
Biological Process:	• microtubule-based movement

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004520 (mRNA)
NP_004511 (protein)

NM_008442 (mRNA)
NP_032468 (protein)

Location

Chr 5: 61.64 - 61.72 Mb

Chr 13: 108.08 - 108.14 Mb

Pubmed search

[1]

[2]

Kinesin heavy chain member 2A, also known as KIF2A, is a human gene.^[1]

Kinesins, such as KIF2, are microtubule-associated motor proteins. For background information on kinesins, see MIM 148760.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: KIF2A kinesin heavy chain member 2A.

[edit] Further reading

Manning AL, Ganem NJ, Bakhoum SF, et al. (2007). "The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.". Mol. Biol. Cell 18 (8): 2970-9. doi:10.1091/mbc.E07-02-0110. PMID 17538014.
Schepis A, Stauber T, Krijnse Locker J (2008). "Kinesin-1 plays multiple roles during the vaccinia virus life cycle.". Cell. Microbiol. 9 (8): 1960-73. doi:10.1111/j.1462-5822.2007.00927.x. PMID 17394562.
Li C, Zheng Y, Qin W, et al. (2006). "A family-based association study of kinesin heavy chain member 2 gene (KIF2) and schizophrenia.". Neurosci. Lett. 407 (2): 151-5. doi:10.1016/j.neulet.2006.08.025. PMID 16959419.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391-6. doi:10.1073/pnas.0507066103. PMID 16565220.
Ganem NJ, Upton K, Compton DA (2006). "Efficient mitosis in human cells lacking poleward microtubule flux.". Curr. Biol. 15 (20): 1827-32. doi:10.1016/j.cub.2005.08.065. PMID 16243029.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ganem NJ, Compton DA (2004). "The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK.". J. Cell Biol. 166 (4): 473-8. doi:10.1083/jcb.200404012. PMID 15302853.
Johnson JM, Castle J, Garrett-Engele P, et al. (2004). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.". Science 302 (5653): 2141-4. doi:10.1126/science.1090100. PMID 14684825.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Debernardi S, Fontanella E, De Gregorio L, et al. (1997). "Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique.". Genomics 42 (1): 67-73. doi:10.1006/geno.1997.4720. PMID 9177777.