KIF20A

From Wikipedia, the free encyclopedia

Kinesin family member 20A

Identifiers

KIF20A; MKLP2; FLJ21151; RAB6KIFL

External IDs

OMIM: 605664 MGI: 1201682 HomoloGene: 38093

Gene ontology
Molecular Function:	• nucleotide binding • microtubule motor activity • transporter activity • ATP binding
Cellular Component:	• Golgi apparatus • microtubule • microtubule associated complex
Biological Process:	• microtubule-based movement • protein transport • vesicle-mediated transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005733 (mRNA)
NP_005724 (protein)

NM_009004 (mRNA)
NP_033030 (protein)

Location

Chr 5: 137.54 - 137.55 Mb

Chr 18: 34.75 - 34.76 Mb

Pubmed search

[1]

[2]

Kinesin family member 20A, also known as KIF20A, is a human gene.^[1]

[edit] References

^ Entrez Gene: KIF20A kinesin family member 20A.

[edit] Further reading

Miki H, Setou M, Kaneshiro K, Hirokawa N (2001). "All kinesin superfamily protein, KIF, genes in mouse and human.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7004–11. doi:10.1073/pnas.111145398. PMID 11416179.
Echard A, Jollivet F, Martinez O, et al. (1998). "Interaction of a Golgi-associated kinesin-like protein with Rab6.". Science 279 (5350): 580–5. PMID 9438855.
Horrevoets AJ, Fontijn RD, van Zonneveld AJ, et al. (1999). "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes.". Blood 93 (10): 3418–31. PMID 10233894.
Lai F, Fernald AA, Zhao N, Le Beau MM (2000). "cDNA cloning, expression pattern, genomic structure and chromosomal location of RAB6KIFL, a human kinesin-like gene.". Gene 248 (1-2): 117–25. PMID 10806357.
Opdam FJ, Echard A, Croes HJ, et al. (2000). "The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus.". J. Cell. Sci. 113 ( Pt 15): 2725–35. PMID 10893188.
Hill E, Clarke M, Barr FA (2000). "The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis.". EMBO J. 19 (21): 5711–9. doi:10.1093/emboj/19.21.5711. PMID 11060022.
Echard A, Opdam FJ, de Leeuw HJ, et al. (2001). "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms.". Mol. Biol. Cell 11 (11): 3819–33. PMID 11071909.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Nagura M, Nagao Y, Takita J, et al. (2003). "The kinesin superfamily protein Rab6KIFL is not involved in the pathophysiology of Charcot-Marie-Tooth disease type 4C.". Int. J. Mol. Med. 11 (1): 45–7. PMID 12469216.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Neef R, Preisinger C, Sutcliffe J, et al. (2003). "Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis.". J. Cell Biol. 162 (5): 863–75. doi:10.1083/jcb.200306009. PMID 12939256.
Gruneberg U, Neef R, Honda R, et al. (2004). "Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2.". J. Cell Biol. 166 (2): 167–72. doi:10.1083/jcb.200403084. PMID 15263015.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Taniuchi K, Nakagawa H, Nakamura T, et al. (2005). "Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell.". Cancer Res. 65 (1): 105–12. PMID 15665285.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.