Keratan sulfotransferase

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In enzymology, a keratan sulfotransferase (EC 2.8.2.21) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + keratan adenosine 3',5'-bisphosphate + keratan 6'-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and keratan, whereas its two products are adenosine 3',5'-bisphosphate and keratan 6'-sulfate.

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:keratan 6'-sulfotransferase. Other names in common use include 3'-phosphoadenylyl keratan sulfotransferase, keratan sulfate sulfotransferase, and 3'-phosphoadenylylsulfate:keratan sulfotransferase.

[edit] References

• IUBMB entry for 2.8.2.21
• BRENDA references for 2.8.2.21 (Recommended.)
• PubMed references for 2.8.2.21
• PubMed Central references for 2.8.2.21
• Google Scholar references for 2.8.2.21
• Ruter ER, Kresse H (1984). "Partial purification and characterization of 3'-phosphoadenylylsulfate:keratan sulfate sulfotransferases". J. Biol. Chem. 259: 11771–6. PMID 6592165. 

[edit] External links

The CAS registry number for this enzyme class is 62168-79-0.

• IUBMB entry for 2.8.2.21

• KEGG entry for 2.8.2.21

• BRENDA entry for 2.8.2.21

• NiceZyme view of 2.8.2.21

• EC2PDB: PDB structures for 2.8.2.21

• PRIAM entry for 2.8.2.21

• PUMA2 entry for 2.8.2.21

• IntEnz: Integrated Enzyme entry for 2.8.2.21

• MetaCyc entry for 2.8.2.21

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0045130: keratan sulfotransferase

• AMIGO entry for GO code 0045130: keratan sulfotransferase