Image:Keratinfl.jpg

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Fluorescence microscopy of keratin intermediate filaments in epithelial cells.

Cultured MDCK epithelial cells were stained for keratin, desmoplakin, and DNA (green). The stained cells were visualized by scanning laser confocal microscopy. The image shows how keratin cytoskeletal filaments (most of the red stain) are concentrated around the edge of the cells and merge into the desmoplakin which is located at desmosomes of the surface membrane. The network of keratin to desmosome to keratin linking the cells of an epithelial sheet is what holds together tissues like skin.

Source: my personal image (John Schmidt and my student Caren Handsaker).

Uploaded for use in the Intermediate filament page.

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