KCNK5

From Wikipedia, the free encyclopedia

Potassium channel, subfamily K, member 5

Identifiers

KCNK5; FLJ11035; K2p5.1; TASK-2; TASK2

External IDs

OMIM: 603493 MGI: 1336175 HomoloGene: 2773

Gene ontology
Molecular Function:	• voltage-gated ion channel activity • potassium channel activity • potassium ion binding
Cellular Component:	• membrane fraction • integral to plasma membrane • membrane
Biological Process:	• ion transport • potassium ion transport • excretion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_003740 (mRNA)
NP_003731 (protein)

NM_021542 (mRNA)
NP_067517 (protein)

Location

Chr 6: 39.26 - 39.31 Mb

Chr 14: 18.93 - 18.97 Mb

Pubmed search

[1]

[2]

Potassium channel, subfamily K, member 5, also known as KCNK5, is a human gene.^[1]

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport.^[1]

[edit] References

^ ^a ^b Entrez Gene: KCNK5 potassium channel, subfamily K, member 5.

[edit] Further reading

Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits.". Nat. Rev. Neurosci. 2 (3): 175–84. PMID 11256078.
Goldstein SA, Bayliss DA, Kim D, et al. (2006). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels.". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Reyes R, Duprat F, Lesage F, et al. (1998). "Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney.". J. Biol. Chem. 273 (47): 30863–9. PMID 9812978.
Gray AT, Zhao BB, Kindler CH, et al. (2000). "Volatile anesthetics activate the human tandem pore domain baseline K+ channel KCNK5.". Anesthesiology 92 (6): 1722–30. PMID 10839924.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Morton MJ, O'Connell AD, Sivaprasadarao A, Hunter M (2003). "Determinants of pH sensing in the two-pore domain K(+) channels TASK-1 and -2.". Pflugers Arch. 445 (5): 577–83. doi:10.1007/s00424-002-0901-2. PMID 12634929.
Niemeyer MI, Cid LP, Valenzuela X, et al. (2004). "Extracellular conserved cysteine forms an intersubunit disulphide bridge in the KCNK5 (TASK-2) K+ channel without having an essential effect upon activity.". Mol. Membr. Biol. 20 (2): 185–91. doi:10.1080/0968768031000084181. PMID 12851074.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Rusznák Z, Pocsai K, Kovács I, et al. (2004). "Differential distribution of TASK-1, TASK-2 and TASK-3 immunoreactivities in the rat and human cerebellum.". Cell. Mol. Life Sci. 61 (12): 1532–42. doi:10.1007/s00018-004-4082-3. PMID 15197476.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.