Talk:Itraconazole

From Wikipedia, the free encyclopedia

	Itraconazole is part of WikiProject Pharmacology, a project to improve all Pharmacology-related articles. If you would like to help improve this and other pharmacology articles, please join the project. All interested editors are welcome.
Start	This article has been rated as start-Class on the quality scale.
Mid	This article has been rated as mid-importance for this Project's importance scale.

Contents 1 Scary wrong 2 Itraconazole HAS been prescribed for fungal meningitis 3 In conclusion, itraconazole HAS been prescribed as treatment for meningitis. I was not wrong. 4 it says it right there! 5 read carefully!

[edit] Scary wrong

Whoever wrote that neurologists use itraconazole for CNS infections, good luck. The drug doesn't enter CNS. - Emt147 ^Burninate! 01:07, 27 December 2006 (UTC)

[edit] Itraconazole HAS been prescribed for fungal meningitis

Actually, as I wrote, it has been prescribed for fungal meningitis, specifically meningitis caused by the spores of valley which are inhaled, causing pneumonia and then moves to infect the meninges, which is called fungal meningitis.

Here is my source which you can access; can you provide your source which I can access electronically?

"Itraconazole was reported to be potentially efficacious for coccidioidal meningitis" Citation: Tucker RM, Denning DW, Dupont B, Stevens DA. Itraconazole therapy for chronic coccidioidal meningitis. Ann Intern Med 1990; 112:108–12.

It has also been used in cats and dogs: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B75BB-4HDNVHP-5&_user=4421&_coverDate=11%2F30%2F2005&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000059598&_version=1&_urlVersion=0&_userid=4421&md5=8d6f9031c7864edee2844bdcddb74a01#SECX8

128.120.57.223 23:49, 15 February 2007 (UTC)

My source is the Sanford Guide to Antimicrobial Therapy and clinical experience. You might be able to reach therapeutic CNS levels over time but certainly not in acute infections, and cocci meningitis is rather uncommon. To quote the Hopkins Antibiotic Guide (http://www.hopkins-abxguide.org), Negligible CSF penetration, however treatment has been successful for cryptococcal and coccidioidal meningitis. - Emt147 ^Burninate! 05:26, 16 February 2007 (UTC)

[edit] In conclusion, itraconazole HAS been prescribed as treatment for meningitis. I was not wrong.

71.137.214.216 14:42, 8 March 2007 (UTC)

[edit] it says it right there!

it doesn't seem as though the source of the information is not credible, rather that the information extrapolated from that source is incorrectly stated on this wiki page

you have just admitted that therapeutic levels can be obtained over time, and that itraconazole can be effective for treating cocci meningitis, regardless of how common it is or not.

To quote Sanford's (the leading guide for antimicrobial therapy used by physicians): "do not use to treat meningitis". If you have a better source, cite it. Removing cited material is vandalism and I will treat it as such. - Emt147 ^Burninate! 23:48, 24 May 2007 (UTC)

[edit] read carefully!

Again, I am NOT questioning your source; I am questioning YOUR interpretation of the information. To quote YOUR source the second line agent for coccidioides immitis (a fungus causing MENINGITIS) is ITRACONAZOLE! (http://www.hopkins-abxguide.org/terminals/diagnosis_more.cfm?id=26&fc=pt)

The source is perfectly correct; it is YOU who are mistaken. Read your source thoroughly next time for clarification.

YOU quoted Hopkins supporting the fact that itraconazole CAN be used to treat meningitis "Negligible CSF penetration, however treatment has been successful for cryptococcal and coccidioidal meningitis" (http://www.hopkins-abxguide.org/terminals/antibiotics_more.cfm?id=81&fc=p), just in case you did not understand that statement I will repeat it, "TREATMENT HAS BEEN SUCCESSFUL FOR CRYPTOCOCCAL AND COCCIDIOIDAL MENINGITIS"(http://www.hopkins-abxguide.org/terminals/antibiotics_more.cfm?id=81&fc=p), you even quoted that same line yourself!

Btw, I’m pretty sure YOU didn't site or give a link to the exact page of your 'new' information. Where does it say, "do not use [itraconazole] to treat meningitis" as I have just pointed out, Itraconazole is used in patients who do not respond well to Fluconazole and/or Amphotericin b

I do not think you understand the severity of your misinformation. Patients, doctors, and families can look upon this information for a victim of coccidiodal meningitis and suggest the use of itraconazole, but if you continue to insist that itraconazole cannot be used for meningitis, you dangerously mislead vulnerable people. Unless you have definitive, non contradicting information, please stop claiming that itraconazole cannot be used for meningitis. To be clear, it is not used for all types of meningitis, but it does work for the 2 mentioned above.

If you do provide definitive proof that Itraconazole cannot be used for coccidioidal meningitis, I would genuinely appreciate the quote and source if the information. Apr03 08:38, 28 May 2007 (UTC)