ITPKB

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Inositol 1,4,5-trisphosphate 3-kinase B
PDB rendering based on 2aqx.
Available structures: 2aqx
Identifiers
Symbol(s)	ITPKB; IP3K; IP3K-B; PIG37
External IDs	OMIM: 147522 MGI: 109235 HomoloGene: 1672
Gene ontology Molecular Function: • nucleotide binding • calmodulin binding • ATP binding • inositol trisphosphate 3-kinase activity • kinase activity • transferase activity Biological Process: • MAPKKK cascade • cell surface receptor linked signal transduction • T cell differentiation • positive thymic T cell selection • positive regulation of Ras protein signal transduction • positive regulation of alpha-beta T cell differentiation
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	3707	320404
Ensembl	ENSG00000143772	ENSMUSG00000038855
Uniprot	P27987	n/a
Refseq	NM_002221 (mRNA) NP_002212 (protein)	XM_205854 (mRNA) XP_205854 (protein)
Location	Chr 1: 224.89 - 224.99 Mb	Chr 1: 182.17 - 182.26 Mb
Pubmed search	[1]	[2]

Inositol 1,4,5-trisphosphate 3-kinase B, also known as ITPKB, is a human gene.

The protein encoded by this gene regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity.^[1]

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