ITLN1

From Wikipedia, the free encyclopedia

Intelectin 1 (galactofuranose binding)

Identifiers

ITLN1; HL1; FLJ20022; HL-1; INTL; ITLN; LFR; hIntL; omentin

External IDs

OMIM: 609873 MGI: 3057189 HomoloGene: 79454

Gene ontology
Molecular Function:	• receptor binding • sugar binding • GPI anchor binding
Cellular Component:	• membrane
Biological Process:	• signal transduction

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_017625 (mRNA)
NP_060095 (protein)

NM_001007552 (mRNA)
NP_001007553 (protein)

Location

Chr 1: 159.11 - 159.12 Mb

n/a

Pubmed search

[1]

[2]

Intelectin 1 (galactofuranose binding), also known as ITLN1, is a human gene.^[1]

[edit] References

^ Entrez Gene: ITLN1 intelectin 1 (galactofuranose binding).

[edit] Further reading

Suzuki YA, Lopez V, Lönnerdal B (2006). "Mammalian lactoferrin receptors: structure and function.". Cell. Mol. Life Sci. 62 (22): 2560–75. doi:10.1007/s00018-005-5371-1. PMID 16261254.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Lee JK, Schnee J, Pang M, et al. (2001). "Human homologs of the Xenopus oocyte cortical granule lectin XL35.". Glycobiology 11 (1): 65–73. PMID 11181563.
Tsuji S, Uehori J, Matsumoto M, et al. (2001). "Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall.". J. Biol. Chem. 276 (26): 23456–63. doi:10.1074/jbc.M103162200. PMID 11313366.
Suzuki YA, Shin K, Lönnerdal B (2002). "Molecular cloning and functional expression of a human intestinal lactoferrin receptor.". Biochemistry 40 (51): 15771–9. PMID 11747454.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Chang BY, Peavy TR, Wardrip NJ, Hedrick JL (2004). "The Xenopus laevis cortical granule lectin: cDNA cloning, developmental expression, and identification of the eglectin family of lectins.". Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 137 (1): 115–29. PMID 14720597.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wali A, Morin PJ, Hough CD, et al. (2005). "Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE).". Lung Cancer 48 (1): 19–29. doi:10.1016/j.lungcan.2004.10.011. PMID 15777968.
Schäffler A, Neumeier M, Herfarth H, et al. (2006). "Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue.". Biochim. Biophys. Acta 1732 (1-3): 96–102. doi:10.1016/j.bbaexp.2005.11.005. PMID 16386808.
Yang RZ, Lee MJ, Hu H, et al. (2006). "Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action.". Am. J. Physiol. Endocrinol. Metab. 290 (6): E1253–61. doi:10.1152/ajpendo.00572.2004. PMID 16531507.
Schäffler A, Zeitoun M, Wobser H, et al. (2007). "Frequency and significance of the novel single nucleotide missense polymorphism Val109Asp in the human gene encoding omentin in Caucasian patients with type 2 diabetes mellitus or chronic inflammatory bowel diseases.". Cardiovascular diabetology 6: 3. doi:10.1186/1475-2840-6-3. PMID 17295929.
Wurm S, Neumeier M, Weigert J, et al. (2007). "Plasma levels of leptin, omentin, collagenous repeat-containing sequence of 26-kDa protein (CORS-26) and adiponectin before and after oral glucose uptake in slim adults.". Cardiovascular diabetology 6: 7. doi:10.1186/1475-2840-6-7. PMID 17311679.
de Souza Batista CM, Yang RZ, Lee MJ, et al. (2007). "Omentin plasma levels and gene expression are decreased in obesity.". Diabetes 56 (6): 1655–61. doi:10.2337/db06-1506. PMID 17329619.