ITIH3

From Wikipedia, the free encyclopedia

Inter-alpha (globulin) inhibitor H3

Identifiers

External IDs

OMIM: 146650 MGI: 96620 HomoloGene: 1669

Gene ontology
Molecular Function:	• serine-type endopeptidase inhibitor activity
Cellular Component:	• extracellular region
Biological Process:	• hyaluronan metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002217 (mRNA)
NP_002208 (protein)

NM_008407 (mRNA)
NP_032433 (protein)

Location

Chr 3: 52.8 - 52.82 Mb

Chr 14: 29.74 - 29.75 Mb

Pubmed search

[1]

[2]

Inter-alpha (globulin) inhibitor H3, also known as ITIH3, is a human gene.^[1]

[edit] References

^ Entrez Gene: ITIH3 inter-alpha (globulin) inhibitor H3.

[edit] Further reading

Jean L, Risler JL, Nagase T, et al. (1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. 446 (1): 6-8. PMID 10100603.
Salier JP, Simon D, Rouet P, et al. (1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily.". Genomics 14 (1): 83-8. PMID 1385302.
Enghild JJ, Salvesen G, Hefta SA, et al. (1991). "Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor.". J. Biol. Chem. 266 (2): 747-51. PMID 1898736.
Salier JP, Diarra-Mehrpour M, Sesboue R, et al. (1988). "Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI.". Proc. Natl. Acad. Sci. U.S.A. 84 (23): 8272-6. PMID 2446322.
Diarra-Mehrpour M, Bourguignon J, Sesboüé R, et al. (1989). "Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes.". Eur. J. Biochem. 179 (1): 147-54. PMID 2465147.
Enghild JJ, Thøgersen IB, Pizzo SV, Salvesen G (1989). "Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan.". J. Biol. Chem. 264 (27): 15975-81. PMID 2476436.
Diarra-Mehrpour M, Bourguignon J, Sarafan N, et al. (1994). "Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes.". Biochim. Biophys. Acta 1219 (2): 551-4. PMID 7522574.
Bourguignon J, Diarra-Mehrpour M, Thiberville L, et al. (1993). "Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence.". Eur. J. Biochem. 212 (3): 771-6. PMID 7681778.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Blom AM, Thuveson M, Fries E (1998). "Intracellular coupling of bikunin and the heavy chain of rat pre-alpha-inhibitor in COS-1 cells.". Biochem. J. 328 ( Pt 1): 185-91. PMID 9359851.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Diarra-Mehrpour M, Sarafan N, Bourguignon J, et al. (1998). "Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage.". J. Biol. Chem. 273 (41): 26809-19. PMID 9756925.
Thuveson M, Fries E (1999). "Intracellular proteolytic processing of the heavy chain of rat pre-alpha-inhibitor. The COOH-terminal propeptide is required for coupling to bikunin.". J. Biol. Chem. 274 (10): 6741-6. PMID 10037773.
Bourguignon J, Borghi H, Sesboüé R, et al. (1999). "Immunohistochemical distribution of inter-alpha-trypsin inhibitor chains in normal and malignant human lung tissue.". J. Histochem. Cytochem. 47 (12): 1625-32. PMID 10567446.
Thuveson M, Fries E (2000). "The low pH in trans-Golgi triggers autocatalytic cleavage of pre-alpha -inhibitor heavy chain precursor.". J. Biol. Chem. 275 (40): 30996-1000. doi:10.1074/jbc.M002399200. PMID 10893227.
Kato M, Seki N, Sugano S, et al. (2002). "Identification of sonic hedgehog-responsive genes using cDNA microarray.". Biochem. Biophys. Res. Commun. 289 (2): 472-8. doi:10.1006/bbrc.2001.5976. PMID 11716497.
Paris S, Sesboüé R, Delpech B, et al. (2002). "Inhibition of tumor growth and metastatic spreading by overexpression of inter-alpha-trypsin inhibitor family chains.". Int. J. Cancer 97 (5): 615-20. PMID 11807786.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.