ITGB7

From Wikipedia, the free encyclopedia

Integrin, beta 7

PDB rendering based on 2brq.

Available structures: 2brq

Identifiers

Symbol(s)

ITGB7;

External IDs

OMIM: 147559 MGI: 96616 HomoloGene: 20247

Gene ontology
Molecular Function:	• receptor activity • identical protein binding
Cellular Component:	• integrin complex • membrane • integral to membrane
Biological Process:	• cell adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • multicellular organismal development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000889 (mRNA)
NP_000880 (protein)

NM_013566 (mRNA)
NP_038594 (protein)

Location

Chr 12: 51.87 - 51.89 Mb

Chr 15: 102.04 - 102.06 Mb

Pubmed search

[1]

[2]

Integrin, beta 7, also known as ITGB7, is a human gene.^[1]

[edit] References

^ Entrez Gene: ITGB7 integrin, beta 7.

[edit] Further reading

Rüegg C, Postigo AA, Sikorski EE, et al. (1992). "Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering.". J. Cell Biol. 117 (1): 179-89. PMID 1372909.
Chan BM, Elices MJ, Murphy E, Hemler ME (1992). "Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY.". J. Biol. Chem. 267 (12): 8366-70. PMID 1373725.
Jiang WM, Jenkins D, Yuan Q, et al. (1992). "The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1.". Int. Immunol. 4 (9): 1031-40. PMID 1382574.
Baker E, Sutherland GR, Jiang WM, et al. (1992). "Mapping of the human integrin beta 7 gene (ITG beta 7) to 12q13.13 by non-isotopic in situ hybridization.". Mamm. Genome 2 (4): 272-3. PMID 1543919.
Yuan QA, Jiang WM, Krissansen GW, Watson JD (1992). "Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains.". Int. Immunol. 3 (12): 1373-4. PMID 1777426.
Erle DJ, Rüegg C, Sheppard D, Pytela R (1991). "Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes.". J. Biol. Chem. 266 (17): 11009-16. PMID 2040616.
Yuan QA, Jiang WM, Krissansen GW, Watson JD (1991). "Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains.". Int. Immunol. 2 (11): 1097-108. PMID 2083230.
Erle DJ, Brown T, Christian D, Aris R (1994). "Lung epithelial lining fluid T cell subsets defined by distinct patterns of beta 7 and beta 1 integrin expression.". Am. J. Respir. Cell Mol. Biol. 10 (3): 237-44. PMID 7509610.
Postigo AA, Sánchez-Mateos P, Lazarovits AI, et al. (1993). "Alpha 4 beta 7 integrin mediates B cell binding to fibronectin and vascular cell adhesion molecule-1. Expression and function of alpha 4 integrins on human B lymphocytes.". J. Immunol. 151 (5): 2471-83. PMID 7689608.
Shaw SK, Cepek KL, Murphy EA, et al. (1994). "Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution.". J. Biol. Chem. 269 (8): 6016-25. PMID 8119947.
Tidswell M, Pachynski R, Wu SW, et al. (1997). "Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1.". J. Immunol. 159 (3): 1497-505. PMID 9233649.
Tan K, Casasnovas JM, Liu JH, et al. (1998). "The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition.". Structure 6 (6): 793-801. PMID 9655832.
Rietzler M, Bittner M, Kolanus W, et al. (1998). "The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins.". J. Biol. Chem. 273 (42): 27459-66. PMID 9765275.
Taraszka KS, Higgins JM, Tan K, et al. (2000). "Molecular basis for leukocyte integrin alpha(E)beta(7) adhesion to epithelial (E)-cadherin.". J. Exp. Med. 191 (9): 1555-67. PMID 10790430.
Higgins JM, Cernadas M, Tan K, et al. (2000). "The role of alpha and beta chains in ligand recognition by beta 7 integrins.". J. Biol. Chem. 275 (33): 25652-64. doi:10.1074/jbc.M001228200. PMID 10837471.
Puig-Kröger A, Sanz-Rodríguez F, Longo N, et al. (2000). "Maturation-dependent expression and function of the CD49d integrin on monocyte-derived human dendritic cells.". J. Immunol. 165 (8): 4338-45. PMID 11035069.
Guilliano MJ, Foxx-Orenstein AE, Lebman DA (2001). "The microenvironment of human Peyer's patches inhibits the increase in CD38 expression associated with the germinal center reaction.". J. Immunol. 166 (4): 2179-85. PMID 11160270.
Calderwood DA, Huttenlocher A, Kiosses WB, et al. (2002). "Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration.". Nat. Cell Biol. 3 (12): 1060-8. doi:10.1038/ncb1201-1060. PMID 11781567.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Calderwood DA, Fujioka Y, de Pereda JM, et al. (2003). "Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2272-7. doi:10.1073/pnas.262791999. PMID 12606711.