ITGB3BP

From Wikipedia, the free encyclopedia

Integrin beta 3 binding protein (beta3-endonexin)

Identifiers

ITGB3BP; CENP-R; CENPR; HSU37139; NRIF3; TAP20

External IDs

OMIM: 605494 MGI: 1914983 HomoloGene: 8617

Gene ontology
Molecular Function:	• signal transducer activity • protein C-terminus binding
Cellular Component:	• chromosome, pericentric region • membrane fraction • nucleus • chromosome • cytoplasm
Biological Process:	• transcription • regulation of transcription, DNA-dependent • apoptosis • cell adhesion • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014288 (mRNA)
NP_055103 (protein)

NM_026348 (mRNA)
NP_080624 (protein)

Location

Chr 1: 63.68 - 63.76 Mb

Chr 4: 99.26 - 99.43 Mb

Pubmed search

[1]

[2]

Integrin beta 3 binding protein (beta3-endonexin), also known as ITGB3BP, is a human gene.^[1]

[edit] References

^ Entrez Gene: ITGB3BP integrin beta 3 binding protein (beta3-endonexin).

[edit] Further reading

Shattil SJ, O'Toole T, Eigenthaler M, et al. (1995). "Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit.". J. Cell Biol. 131 (3): 807–16. PMID 7593198.
Kashiwagi H, Schwartz MA, Eigenthaler M, et al. (1997). "Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail.". J. Cell Biol. 137 (6): 1433–43. PMID 9182673.
Li D, Desai-Yajnik V, Lo E, et al. (2000). "NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors.". Mol. Cell. Biol. 19 (10): 7191–202. PMID 10490654.
Tang S, Gao Y, Ware JA (1999). "Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent protein.". J. Cell Biol. 147 (5): 1073–84. PMID 10579726.
Ohtoshi A, Maeda T, Higashi H, et al. (2000). "beta3-endonexin as a novel inhibitor of cyclin A-associated kinase.". Biochem. Biophys. Res. Commun. 267 (3): 947–52. doi:10.1006/bbrc.1999.2007. PMID 10673397.
Li D, Wang F, Samuels HH (2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation.". Mol. Cell. Biol. 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. PMID 11713274.
Fujimoto TT, Katsutani S, Shimomura T, Fujimura K (2002). "Novel alternatively spliced form of beta(3)-endonexin.". Thromb. Res. 105 (1): 63–70. PMID 11864709.
Besta F, Massberg S, Brand K, et al. (2003). "Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor.". J. Cell. Sci. 115 (Pt 20): 3879–88. PMID 12244126.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Li D, Das S, Yamada T, Samuels HH (2004). "The NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cells.". Mol. Cell. Biol. 24 (9): 3838–48. PMID 15082778.
Talukder AH, Gururaj A, Mishra SK, et al. (2004). "Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator.". Mol. Cell. Biol. 24 (15): 6581–91. doi:10.1128/MCB.24.15.6581-6591.2004. PMID 15254226.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Foltz DR, Jansen LE, Black BE, et al. (2006). "The human CENP-A centromeric nucleosome-associated complex.". Nat. Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419.
Okada M, Cheeseman IM, Hori T, et al. (2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.". Nat. Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.