Isoliquiritigenin 2'-O-methyltransferase

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In enzymology, an isoliquiritigenin 2'-O-methyltransferase (EC 2.1.1.154) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + isoliquiritigenin $\rightleftharpoons$ S-adenosyl-L-homocysteine + 2'-O-methylisoliquiritigenin

Thus, the two substrates of this enzyme are S-adenosyl methionine and isoliquiritigenin, whereas its two products are S-adenosylhomocysteine and 2'-O-methylisoliquiritigenin.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:isoliquiritigenin 2'-O-methyltransferase. Other names in common use include chalcone OMT, and CHMT.

[edit] References

IUBMB entry for 2.1.1.154
BRENDA references for 2.1.1.154 (Recommended.)
PubMed references for 2.1.1.154
PubMed Central references for 2.1.1.154
Google Scholar references for 2.1.1.154
Maxwell CA, Edwards R, Dixon RA (1992). "Identification, purification, and characterization of S-adenosyl-L-methionine: isoliquiritigenin 2'-O-methyltransferase from alfalfa (Medicago sativa L.)". Arch. Biochem. Biophys. 293: 158–66. doi:10.1016/0003-9861(92)90379-B. PMID 1731632.
Ichimura M, Furuno T, Takahashi T, Dixon RA, Ayabe S (1997). "Enzymic O-methylation of isoliquiritigenin and licodione in alfalfa and licorice cultures". Phytochemistry. 44: 991–5. doi:10.1016/S0031-9422(96)00670-X. PMID 9055445.