Isoguanine
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| Isoguanine | |
|---|---|
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| IUPAC name | 6-Amino-1,7-dihydropurin-2-one |
| Other names | 2-Hydroxyadenine |
| Identifiers | |
| CAS number | [3373-53-3] |
| PubChem | |
| SMILES | C1=NC2=NC(=O)NC(=C2N1)N |
| Properties | |
| Molecular formula | C5H5N5O |
| Molar mass | 151.1261 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Isoguanine or 2-hydroxyladenine is a purine base that is an isomer of guanine. It is a product of oxidative damage to DNA and has been shown to cause mutation.[1] It is also used in combination with isocytosine in studies of unnatural nucleic acid analogues of the normal base pairs in DNA.
[edit] References
- ^ Yang XL, Sugiyama H, Ikeda S, Saito I, Wang AH (1998). "Structural studies of a stable parallel-stranded DNA duplex incorporating isoguanine:cytosine and isocytosine:guanine basepairs by nuclear magnetic resonance spectroscopy". Biophys. J. 75 (3): 1163–71. PMID 9726918.
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