ISG20

From Wikipedia, the free encyclopedia

Interferon stimulated exonuclease gene 20kDa

PDB rendering based on 1wlj.

Available structures: 1wlj

Identifiers

Symbol(s)

ISG20; CD25; HEM45

External IDs

OMIM: 604533 MGI: 1928895 HomoloGene: 31081

Gene ontology
Molecular Function:	• 3'-5'-exoribonuclease activity • RNA binding • exonuclease activity • single-stranded DNA specific 3'-5' exodeoxyribonuclease activity • exoribonuclease II activity • hydrolase activity • manganese ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus • nucleoplasm • PML body
Biological Process:	• DNA catabolic process, exonucleolytic • RNA catabolic process • cell proliferation • response to virus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002201 (mRNA)
NP_002192 (protein)

NM_020583 (mRNA)
NP_065608 (protein)

Location

Chr 15: 86.98 - 87 Mb

Chr 7: 78.79 - 78.79 Mb

Pubmed search

[1]

[2]

Interferon stimulated exonuclease gene 20kDa, also known as ISG20, is a human gene.^[1]

[edit] References

^ Entrez Gene: ISG20 interferon stimulated exonuclease gene 20kDa.

[edit] Further reading

Gongora C, David G, Pintard L, et al. (1997). "Molecular cloning of a new interferon-induced PML nuclear body-associated protein.". J. Biol. Chem. 272 (31): 19457-63. PMID 9235947.
Pentecost BT (1998). "Expression and estrogen regulation of the HEM45 MRNA in human tumor lines and in the rat uterus.". J. Steroid Biochem. Mol. Biol. 64 (1-2): 25-33. PMID 9569007.
Mattei MG, Tissot C, Gongora C, Mechti N (1998). "Assignment of ISG20 encoding a new interferon-induced PML nuclear body-associated protein, to chromosome 15q26 by in situ hybridization.". Cytogenet. Cell Genet. 79 (3-4): 286-7. PMID 9605874.
Nguyen LH, Espert L, Mechti N, Wilson DM (2001). "The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro.". Biochemistry 40 (24): 7174-9. PMID 11401564.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.". Nat. Med. 9 (2): 191-7. doi:10.1038/nm822. PMID 12539042.
Espert L, Degols G, Gongora C, et al. (2003). "ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses.". J. Biol. Chem. 278 (18): 16151-8. doi:10.1074/jbc.M209628200. PMID 12594219.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Horio T, Murai M, Inoue T, et al. (2005). "Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease.". FEBS Lett. 577 (1-2): 111-6. doi:10.1016/j.febslet.2004.09.074. PMID 15527770.