IRAK3

From Wikipedia, the free encyclopedia

Interleukin-1 receptor-associated kinase 3

Identifiers

IRAK3; IRAK-M

External IDs

OMIM: 604459 MGI: 1921164 HomoloGene: 36215

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • ATP binding • transferase activity • identical protein binding
Biological Process:	• protein amino acid phosphorylation • signal transduction • cytokine and chemokine mediated signaling pathway • regulation of protein complex disassembly

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007199 (mRNA)
NP_009130 (protein)

NM_028679 (mRNA)
NP_082955 (protein)

Location

Chr 12: 64.87 - 64.93 Mb

Chr 10: 119.54 - 119.6 Mb

Pubmed search

[1]

[2]

Interleukin-1 receptor-associated kinase 3, also known as IRAK3, is a human gene.^[1]

[edit] References

^ Entrez Gene: IRAK3 interleukin-1 receptor-associated kinase 3.

[edit] Further reading

Wesche H, Gao X, Li X, et al. (1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family.". J. Biol. Chem. 274 (27): 19403-10. PMID 10383454.
Rosati O, Martin MU (2002). "Identification and characterization of murine IRAK-M.". Biochem. Biophys. Res. Commun. 293 (5): 1472-7. doi:10.1016/S0006-291X(02)00411-4. PMID 12054681.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bin LH, Xu LG, Shu HB (2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling.". J. Biol. Chem. 278 (27): 24526-32. doi:10.1074/jbc.M303451200. PMID 12721283.
Escoll P, del Fresno C, García L, et al. (2004). "Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients.". Biochem. Biophys. Res. Commun. 311 (2): 465-72. PMID 14592437.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
del Fresno C, Otero K, Gómez-García L, et al. (2005). "Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4.". J. Immunol. 174 (5): 3032-40. PMID 15728517.
Su J, Xie Q, Wilson I, Li L (2007). "Differential regulation and role of interleukin-1 receptor associated kinase-M in innate immunity signaling.". Cell. Signal. 19 (7): 1596-601. doi:10.1016/j.cellsig.2007.02.009. PMID 17379480.
Balaci L, Spada MC, Olla N, et al. (2007). "IRAK-M is involved in the pathogenesis of early-onset persistent asthma.". Am. J. Hum. Genet. 80 (6): 1103-14. doi:10.1086/518259. PMID 17503328.
Weersma RK, Oostenbrug LE, Nolte IM, et al. (2007). "Association of interleukin-1 receptor-associated kinase M (IRAK-M) and inflammatory bowel diseases.". Scand. J. Gastroenterol. 42 (7): 827-33. doi:10.1080/00365520601114024. PMID 17558906.
van 't Veer C, van den Pangaart PS, van Zoelen MA, et al. (2007). "Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model.". J. Immunol. 179 (10): 7110-20. PMID 17982103.