IRAK1

From Wikipedia, the free encyclopedia

Interleukin-1 receptor-associated kinase 1

Identifiers

IRAK1; IRAK; pelle

External IDs

OMIM: 300283 MGI: 107420 HomoloGene: 37496

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein kinase activity • protein serine/threonine kinase activity • NF-kappaB-inducing kinase activity • receptor activity • interleukin-1 receptor binding • protein binding • ATP binding • transcription activator activity • transferase activity • protein kinase binding • protein homodimerization activity
Cellular Component:	• interleukin-1 receptor complex
Biological Process:	• protein amino acid phosphorylation • signal transduction • transmembrane receptor protein serine/threonine kinase signaling pathway • activation of NF-kappaB-inducing kinase • cytokine and chemokine mediated signaling pathway • positive regulation of transcription • protein amino acid autophosphorylation • protein oligomerization

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001025242 (mRNA)
NP_001020413 (protein)

NM_008363 (mRNA)
NP_032389 (protein)

Location

Chr X: 152.93 - 152.94 Mb

Chr X: 70.27 - 70.28 Mb

Pubmed search

[1]

[2]

Interleukin-1 receptor-associated kinase 1, also known as IRAK1, is a human gene.

This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ Entrez Gene: IRAK1 interleukin-1 receptor-associated kinase 1.

[edit] Further reading

Auron PE (1999). "The interleukin 1 receptor: ligand interactions and signal transduction.". Cytokine Growth Factor Rev. 9 (3-4): 221–37. PMID 9918122.
Cao Z, Henzel WJ, Gao X (1996). "IRAK: a kinase associated with the interleukin-1 receptor.". Science 271 (5252): 1128–31. PMID 8599092.
Cao Z, Xiong J, Takeuchi M, et al. (1996). "TRAF6 is a signal transducer for interleukin-1.". Nature 383 (6599): 443–6. doi:10.1038/383443a0. PMID 8837778.
Brenner V, Nyakatura G, Rosenthal A, Platzer M (1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse.". Genomics 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695.
Huang J, Gao X, Li S, Cao Z (1998). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein.". Proc. Natl. Acad. Sci. U.S.A. 94 (24): 12829–32. PMID 9371760.
Muzio M, Ni J, Feng P, Dixit VM (1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.". Science 278 (5343): 1612–5. PMID 9374458.
Muzio M, Natoli G, Saccani S, et al. (1998). "The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6).". J. Exp. Med. 187 (12): 2097–101. PMID 9625770.
Maschera B, Ray K, Burns K, Volpe F (1999). "Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB.". Biochem. J. 339 ( Pt 2): 227–31. PMID 10191251.
Wesche H, Gao X, Li X, et al. (1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family.". J. Biol. Chem. 274 (27): 19403–10. PMID 10383454.
Yang RB, Mark MR, Gurney AL, Godowski PJ (1999). "Signaling events induced by lipopolysaccharide-activated toll-like receptor 2.". J. Immunol. 163 (2): 639–43. PMID 10395652.
Thomas JA, Allen JL, Tsen M, et al. (1999). "Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase.". J. Immunol. 163 (2): 978–84. PMID 10395695.
Reichwald K, Thiesen J, Wiehe T, et al. (2000). "Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions.". Mamm. Genome 11 (3): 182–90. PMID 10723722.
Burns K, Clatworthy J, Martin L, et al. (2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.". Nat. Cell Biol. 2 (6): 346–51. doi:10.1038/35014038. PMID 10854325.
Böl G, Kreuzer OJ, Brigelius-Flohé R (2000). "Translocation of the interleukin-1 receptor-associated kinase-1 (IRAK-1) into the nucleus.". FEBS Lett. 477 (1-2): 73–8. PMID 10899313.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Vig E, Green M, Liu Y, et al. (2001). "SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity.". J. Biol. Chem. 276 (11): 7859–66. doi:10.1074/jbc.M010399200. PMID 11096118.
Li X, Commane M, Jiang Z, Stark GR (2001). "IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK).". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4461–5. doi:10.1073/pnas.071054198. PMID 11287640.
Jensen LE, Whitehead AS (2001). "IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability.". J. Biol. Chem. 276 (31): 29037–44. doi:10.1074/jbc.M103815200. PMID 11397809.
Qian Y, Commane M, Ninomiya-Tsuji J, et al. (2001). "IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B.". J. Biol. Chem. 276 (45): 41661–7. doi:10.1074/jbc.M102262200. PMID 11518704.