IQGAP2

From Wikipedia, the free encyclopedia

IQ motif containing GTPase activating protein 2

Identifiers

External IDs

Gene ontology
Molecular Function:	• actin binding • GTPase inhibitor activity • Ras GTPase activator activity • calmodulin binding
Cellular Component:	• intracellular • actin cytoskeleton
Biological Process:	• signal transduction • negative regulation of Ras protein signal transduction • regulation of small GTPase mediated signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_006633 (mRNA)
NP_006624 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 5: 75.73 - 76.04 Mb

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Pubmed search

[1]

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IQ motif containing GTPase activating protein 2, also known as IQGAP2, is a human gene.^[1]

This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility.^[1]

[edit] References

^ ^a ^b Entrez Gene: IQGAP2 IQ motif containing GTPase activating protein 2.

[edit] Further reading

McCallum SJ, Wu WJ, Cerione RA (1996). "Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2.". J. Biol. Chem. 271 (36): 21732-7. PMID 8702968.
Brill S, Li S, Lyman CW, et al. (1996). "The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases.". Mol. Cell. Biol. 16 (9): 4869-78. PMID 8756646.
Yin H, Morioka H, Towle CA, et al. (2001). "Evidence that HAX-1 is an interleukin-1 alpha N-terminal binding protein.". Cytokine 15 (3): 122-37. doi:10.1006/cyto.2001.0891. PMID 11554782.
Wennerberg K, Ellerbroek SM, Liu RY, et al. (2003). "RhoG signals in parallel with Rac1 and Cdc42.". J. Biol. Chem. 277 (49): 47810-7. doi:10.1074/jbc.M203816200. PMID 12376551.
Schmidt VA, Scudder L, Devoe CE, et al. (2003). "IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization.". Blood 101 (8): 3021-8. doi:10.1182/blood-2002-09-2807. PMID 12515716.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216.
Chew CS, Okamoto CT, Chen X, Qin HY (2005). "IQGAPs are differentially expressed and regulated in polarized gastric epithelial cells.". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (2): G376-87. doi:10.1152/ajpgi.00290.2004. PMID 15458922.
Wang H, Huo R, Xu M, et al. (2005). "Cloning and characterization of a novel transcript variant of IQGAP2 in human testis.". DNA Seq. 15 (5-6): 319-25. doi:10.1080/10425170400009012. PMID 15621655.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.