Iohexol

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Iohexol
Systematic (IUPAC) name
5-(acetyl-(2,3-dihydroxypropyl)amino)-N,N'-bis
(2,3-dihydroxypropyl)-2,4,6-triiodo-benzene-1,3-
dicarboxamide
Identifiers
CAS number 66108-95-0
ATC code V08AB02
PubChem 3730
Chemical data
Formula C19H26I3N3O9 
Mol. mass 821.138 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Protein binding Low
Metabolism Nil
Half life Variable
Excretion Renal, unchanged
Therapeutic considerations
Pregnancy cat.

B(US)
Legal status

℞ Prescription only
Routes Intrathecal, intravascular, oral, intracavital

Iohexol is a contrast agent, sold under the trade name Omnipaque. It is available in various concentrations, from 140 to 350 milligrams of iodine per milliliter. Omnipaque 350 is commonly used as a contrast agent during coronary angiography.

The osmolality of iohexol ranges from 322 mOsm/kg—approximately 1.1 times that of blood plasma—to 844 mOsm/kg, almost three times that of blood.[1] Despite this difference, iohexol is still considered a low-osmolality contrast agent; the osmolality of older agents, such as diatrizoate, may be more than twice as high.[2]

[edit] References

  1. ^ GE Healthcare (May 2006). Omnipaque (Iohexol) injection. Product label. DailyMed. U.S. National Library of Medicine. Retrieved on 2007-03-28.
  2. ^ Amersham Health (April 2006). Hypaque (Diatrizoate Meglumine and Diatrizoate Sodium) injection, solution. Product label. DailyMed. U.S. National Library of Medicine. Retrieved on 2007-03-29.

[edit] External links


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