Interleukin 27 receptor, alpha subunit

From Wikipedia, the free encyclopedia

Interleukin 27 receptor, alpha

Identifiers

IL27RA; CRL1; IL27R; TCCR; WSX1; zcytor1

External IDs

OMIM: 605350 MGI: 1355318 HomoloGene: 3562

Gene ontology
Molecular Function:	• transmembrane receptor activity • protein binding • MHC protein binding • exogenous peptide antigen binding • interleukin-27 receptor activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• immune response • cell surface receptor linked signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004843 (mRNA)
NP_004834 (protein)

NM_016671 (mRNA)
NP_057880 (protein)

Location

Chr 19: 14 - 14.03 Mb

Chr 8: 86.92 - 86.93 Mb

Pubmed search

[1]

[2]

Interleukin 27 receptor, alpha is a subunit of the interleukin-27 receptor. IL27RA is its human gene.^[1]

In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.^[1]

[edit] References

^ ^a ^b Entrez Gene: IL27RA interleukin 27 receptor, alpha.

[edit] Further reading

Sprecher CA, Grant FJ, Baumgartner JW, et al. (1998). "Cloning and characterization of a novel class I cytokine receptor.". Biochem. Biophys. Res. Commun. 246 (1): 82-90. doi:10.1006/bbrc.1998.8576. PMID 9600072.
Chen Q, Ghilardi N, Wang H, et al. (2000). "Development of Th1-type immune responses requires the type I cytokine receptor TCCR.". Nature 407 (6806): 916-20. doi:10.1038/35038103. PMID 11057672.
Pflanz S, Timans JC, Cheung J, et al. (2002). "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells.". Immunity 16 (6): 779-90. PMID 12121660.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Takeda A, Hamano S, Yamanaka A, et al. (2003). "Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment.". J. Immunol. 170 (10): 4886-90. PMID 12734330.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Pflanz S, Hibbert L, Mattson J, et al. (2004). "WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27.". J. Immunol. 172 (4): 2225-31. PMID 14764690.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Pradhan A, Lambert QT, Reuther GW (2008). "Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor.". Proc. Natl. Acad. Sci. U.S.A. 104 (47): 18502-7. doi:10.1073/pnas.0702388104. PMID 18003935.