Integrin, beta 5

From Wikipedia, the free encyclopedia

Integrin, beta 5

Identifiers

ITGB5; FLJ26658

External IDs

OMIM: 147561 MGI: 96614 HomoloGene: 20511

Gene ontology
Molecular Function:	• receptor activity • integrin binding • protein binding
Cellular Component:	• integrin complex • membrane • integral to membrane
Biological Process:	• cell adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • multicellular organismal development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001129224 (mRNA)
XP_001129224 (protein)

NM_010580 (mRNA)
NP_034710 (protein)

Location

Chr 3: 125.96 - 126.09 Mb

Chr 16: 33.75 - 33.87 Mb

Pubmed search

[1]

[2]

Integrin, beta 5, also known as ITGB5, is a human gene.^[1]

[edit] References

^ Entrez Gene: ITGB5 integrin, beta 5.

[edit] Further reading

Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization.". Bioessays 23 (7): 628–39. doi:10.1002/bies.1088. PMID 11462216.
Smith JW, Vestal DJ, Irwin SV, et al. (1990). "Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin.". J. Biol. Chem. 265 (19): 11008–13. PMID 1694173.
Adams JC, Watt FM (1991). "Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes.". J. Cell Biol. 115 (3): 829–41. PMID 1918165.
McLean JW, Vestal DJ, Cheresh DA, Bodary SC (1990). "cDNA sequence of the human integrin beta 5 subunit.". J. Biol. Chem. 265 (28): 17126–31. PMID 2211615.
Ramaswamy H, Hemler ME (1990). "Cloning, primary structure and properties of a novel human integrin beta subunit.". EMBO J. 9 (5): 1561–8. PMID 2328726.
Suzuki S, Huang ZS, Tanihara H (1990). "Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 subunit.". Proc. Natl. Acad. Sci. U.S.A. 87 (14): 5354–8. PMID 2371275.
Hu DD, Lin EC, Kovach NL, et al. (1995). "A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5.". J. Biol. Chem. 270 (44): 26232–8. PMID 7592829.
Vogel BE, Lee SJ, Hildebrand A, et al. (1993). "A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectin.". J. Cell Biol. 121 (2): 461–8. PMID 7682219.
Pasqualini R, Bodorova J, Ye S, Hemler ME (1993). "A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies.". J. Cell. Sci. 105 ( Pt 1): 101–11. PMID 7689573.
Lafrenie RM, Wahl LM, Epstein JS, et al. (1996). "HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes.". J. Immunol. 157 (3): 974–7. PMID 8757599.
Rabb H, Barroso-Vicens E, Adams R, et al. (1997). "Alpha-V/beta-3 and alpha-V/beta-5 integrin distribution in neoplastic kidney.". Am. J. Nephrol. 16 (5): 402–8. PMID 8886177.
Liliental J, Chang DD (1998). "Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit.". J. Biol. Chem. 273 (4): 2379–83. PMID 9442085.
Memmo LM, McKeown-Longo P (1998). "The alphavbeta5 integrin functions as an endocytic receptor for vitronectin.". J. Cell. Sci. 111 ( Pt 4): 425–33. PMID 9443892.
Zhang H, Tan SM, Lu J (1998). "cDNA cloning reveals two mouse beta5 integrin transcripts distinct in cytoplasmic domains as a result of alternative splicing.". Biochem. J. 331 ( Pt 2): 631–7. PMID 9531507.
Barillari G, Sgadari C, Palladino C, et al. (1999). "Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin.". J. Immunol. 163 (4): 1929–35. PMID 10438928.
Carriero MV, Del Vecchio S, Capozzoli M, et al. (1999). "Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer.". Cancer Res. 59 (20): 5307–14. PMID 10537314.
Tang S, Gao Y, Ware JA (1999). "Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent protein.". J. Cell Biol. 147 (5): 1073–84. PMID 10579726.
Cirulli V, Beattie GM, Klier G, et al. (2000). "Expression and function of alpha(v)beta(3) and alpha(v)beta(5) integrins in the developing pancreas: roles in the adhesion and migration of putative endocrine progenitor cells.". J. Cell Biol. 150 (6): 1445–60. PMID 10995448.
Albert ML, Kim JI, Birge RB (2001). "alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells.". Nat. Cell Biol. 2 (12): 899–905. doi:10.1038/35046549. PMID 11146654.
Zhou M, Graham R, Russell G, Croucher PI (2001). "MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin.". Biochem. Biophys. Res. Commun. 280 (2): 574–80. doi:10.1006/bbrc.2000.4155. PMID 11162558.