INSRR

From Wikipedia, the free encyclopedia

Insulin receptor-related receptor

Identifiers

External IDs

OMIM: 147671 MGI: 1346037 HomoloGene: 56539

Gene ontology
Molecular Function:	• nucleotide binding • receptor activity • epidermal growth factor receptor activity • ATP binding • transferase activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• protein amino acid phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • male sex determination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014215 (mRNA)
NP_055030 (protein)

NM_011832 (mRNA)
NP_035962 (protein)

Location

Chr 1: 155.08 - 155.1 Mb

Chr 3: 87.88 - 87.9 Mb

Pubmed search

[1]

[2]

Insulin receptor-related receptor, also known as INSRR, is a human gene.^[1]

[edit] References

^ Entrez Gene: INSRR insulin receptor-related receptor.

[edit] Further reading

Zhang B, Roth RA (1992). "The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities.". J. Biol. Chem. 267 (26): 18320–8. PMID 1326521.
Shier P, Willard HF, Watt VM (1991). "Localization of the insulin receptor-related receptor gene to human chromosome 1.". Cytogenet. Cell Genet. 54 (1-2): 80–1. PMID 2249481.
Shier P, Watt VM (1989). "Primary structure of a putative receptor for a ligand of the insulin family.". J. Biol. Chem. 264 (25): 14605–8. PMID 2768234.
Mathi SK, Chan J, Watt VM (1995). "Insulin receptor-related receptor messenger ribonucleic acid: quantitative distribution and localization to subpopulations of epithelial cells in stomach and kidney.". Endocrinology 136 (9): 4125–32. PMID 7649121.
Kovacina KS, Roth RA (1995). "Characterization of the endogenous insulin receptor-related receptor in neuroblastomas.". J. Biol. Chem. 270 (4): 1881–7. PMID 7829525.
Jui HY, Accili D, Taylor SI (1996). "Characterization of a hybrid receptor formed by dimerization of the insulin receptor-related receptor (IRR) with the insulin receptor (IR): coexpression of cDNAs encoding human IRR and human IR in NIH-3T3 cells.". Biochemistry 35 (45): 14326–30. doi:10.1021/bi9613032. PMID 8916919.
Hänze J, Berthold A, Klammt J, et al. (1999). "Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor.". Horm. Metab. Res. 31 (2-3): 77–9. PMID 10226785.
Xu P, Jacobs AR, Taylor SI (1999). "Interaction of insulin receptor substrate 3 with insulin receptor, insulin receptor-related receptor, insulin-like growth factor-1 receptor, and downstream signaling proteins.". J. Biol. Chem. 274 (21): 15262–70. PMID 10329736.
Elmlinger MW, Rauschnabel U, Koscielniak E, et al. (1999). "Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin.". Regul. Pept. 84 (1-3): 37–42. PMID 10535406.
Whitmore TE, Maurer MF, Day HL, et al. (2000). "The assignment of the human insulin receptor-related receptor gene (INSRR) to chromosome 1q21-->q23 by the use of radiation hybrid mapping.". Cytogenet. Cell Genet. 87 (1-2): 93–4. PMID 10640820.
Weber A, Huesken C, Bergmann E, et al. (2004). "Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas.". Clin. Cancer Res. 9 (15): 5683–92. PMID 14654552.
Klammt J, Garten A, Barnikol-Oettler A, et al. (2005). "Comparative analysis of the signaling capabilities of the insulin receptor-related receptor.". Biochem. Biophys. Res. Commun. 327 (2): 557–64. doi:10.1016/j.bbrc.2004.12.039. PMID 15629149.
Dissen GA, Garcia-Rudaz C, Tapia V, et al. (2006). "Expression of the insulin receptor-related receptor is induced by the preovulatory surge of luteinizing hormone in thecal-interstitial cells of the rat ovary.". Endocrinology 147 (1): 155–65. doi:10.1210/en.2005-0386. PMID 16195402.