INSIG1

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Insulin induced gene 1
Identifiers
Symbol(s) INSIG1; CL-6; MGC1405
External IDs OMIM: 602055 MGI: 1916289 HomoloGene: 4047
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3638 231070
Ensembl ENSG00000186480 ENSMUSG00000045294
Uniprot O15503 Q3UX30
Refseq NM_005542 (mRNA)
NP_005533 (protein)		 NM_153526 (mRNA)
NP_705746 (protein)
Location Chr 7: 154.72 - 154.73 Mb Chr 5: 28.4 - 28.41 Mb
Pubmed search [1] [2]

Insulin induced gene 1, also known as INSIG1, is a human gene.[1]

Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[1]

[edit] References

  1. ^ a b Entrez Gene: INSIG1 insulin induced gene 1.

[edit] Further reading

  • Peng Y, Schwarz EJ, Lazar MA, et al. (1997). "Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene.". Genomics 43 (3): 278-84. doi:10.1006/geno.1997.4821. PMID 9268630. 
  • Kaneda A, Kaminishi M, Nakanishi Y, et al. (2002). "Reduced expression of the insulin-induced protein 1 and p41 Arp2/3 complex genes in human gastric cancers.". Int. J. Cancer 100 (1): 57-62. doi:10.1002/ijc.10464. PMID 12115587. 
  • Yang T, Espenshade PJ, Wright ME, et al. (2002). "Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.". Cell 110 (4): 489-500. PMID 12202038. 
  • Yabe D, Brown MS, Goldstein JL (2002). "Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12753-8. doi:10.1073/pnas.162488899. PMID 12242332. 
  • Janowski BA (2002). "The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP.". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12675-80. doi:10.1073/pnas.202471599. PMID 12242342. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Yabe D, Xia ZP, Adams CM, Rawson RB (2003). "Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16672-7. doi:10.1073/pnas.262669399. PMID 12482938. 
  • Sever N, Yang T, Brown MS, et al. (2003). "Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain.". Mol. Cell 11 (1): 25-33. PMID 12535518. 
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767-72. doi:10.1126/science.1083423. PMID 12690205. 
  • Dobrosotskaya IY, Goldstein JL, Brown MS, Rawson RB (2003). "Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs.". J. Biol. Chem. 278 (37): 35837-43. doi:10.1074/jbc.M306476200. PMID 12842885. 
  • Li J, Takaishi K, Cook W, et al. (2003). "Insig-1 "brakes" lipogenesis in adipocytes and inhibits differentiation of preadipocytes.". Proc. Natl. Acad. Sci. U.S.A. 100 (16): 9476-81. doi:10.1073/pnas.1133426100. PMID 12869692. 
  • Adams CM, Goldstein JL, Brown MS (2003). "Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles.". Proc. Natl. Acad. Sci. U.S.A. 100 (19): 10647-52. doi:10.1073/pnas.1534833100. PMID 12963821. 
  • Feramisco JD, Goldstein JL, Brown MS (2004). "Membrane topology of human insig-1, a protein regulator of lipid synthesis.". J. Biol. Chem. 279 (9): 8487-96. doi:10.1074/jbc.M312623200. PMID 14660594. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Engelking LJ, Kuriyama H, Hammer RE, et al. (2004). "Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.". J. Clin. Invest. 113 (8): 1168-75. doi:10.1172/JCI200420978. PMID 15085196. 
  • Sever N, Lee PC, Song BL, et al. (2004). "Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.". J. Biol. Chem. 279 (41): 43136-47. doi:10.1074/jbc.M406406200. PMID 15247248. 
  • Lee JN, Ye J (2004). "Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1.". J. Biol. Chem. 279 (43): 45257-65. doi:10.1074/jbc.M408235200. PMID 15304479. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Suchanek M, Radzikowska A, Thiele C (2005). "Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells.". Nat. Methods 2 (4): 261-7. doi:10.1038/nmeth752. PMID 15782218. 
  • Sun LP, Li L, Goldstein JL, Brown MS (2005). "Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.". J. Biol. Chem. 280 (28): 26483-90. doi:10.1074/jbc.M504041200. PMID 15899885. 
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