Inositol-trisphosphate 3-kinase

From Wikipedia, the free encyclopedia

In enzymology, an inositol-trisphosphate 3-kinase (EC 2.7.1.127) is an enzyme that catalyzes the chemical reaction

ATP + 1D-myo-inositol 1,4,5-trisphosphate $\rightleftharpoons$ ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate

Thus, the two substrates of this enzyme are ATP and 1D-myo-inositol 1,4,5-trisphosphate, whereas its two products are ADP and 1D-myo-inositol 1,3,4,5-tetrakisphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase. Other names in common use include 1D-myo-inositol-trisphosphate 3-kinase, and Ins(1,4,5)P3 3-kinase. This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, calcium signaling pathway, and phosphatidylinositol signaling system. This enzyme has at least one effector, Calcium.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1TZD, 2A98, and 2AQX.

[edit] References

IUBMB entry for 2.7.1.127
BRENDA references for 2.7.1.127 (Recommended.)
PubMed references for 2.7.1.127
PubMed Central references for 2.7.1.127
Google Scholar references for 2.7.1.127
Hansen CA, Mah S, Williamson JR (1986). "Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver". J. Biol. Chem. 261: 8100–3. PMID 3487541.
Irvine RF, Letcher AJ, Heslop JP, Berridge MJ (1986). "The inositol tris/tetrakisphosphate pathway — demonstration of Ins(1,4,5)P3 3-kinase activity in animal tissues". Nature. 320: 631–4. doi:10.1038/320631a0. PMID 3010126.
Irvine RF, Schell MJ (2001). "Back in the water: the return of the inositol phosphates". Nat. Rev. Mol. Cell. Biol. 2: 327–38. doi:10.1038/35073015. PMID 11331907.