Indolepyruvate ferredoxin oxidoreductase

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In enzymology, an indolepyruvate ferredoxin oxidoreductase (EC 1.2.7.8) is an enzyme that catalyzes the chemical reaction

(indol-3-yl)pyruvate + CoA + oxidized ferredoxin $\rightleftharpoons$ S-2-(indol-3-yl)acetyl-CoA + CO₂ + reduced ferredoxin

The 3 substrates of this enzyme are (indol-3-yl)pyruvate, CoA, and oxidized ferredoxin, whereas its 3 products are S-2-(indol-3-yl)acetyl-CoA, CO₂, and reduced ferredoxin.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is 3-(indol-3-yl)pyruvate:ferredoxin oxidoreductase (decarboxylating, CoA-indole-acetylating). Other names in common use include 3-(indol-3-yl)pyruvate synthase (ferredoxin), and IOR.

[edit] References

IUBMB entry for 1.2.7.8
BRENDA references for 1.2.7.8 (Recommended.)
PubMed references for 1.2.7.8
PubMed Central references for 1.2.7.8
Google Scholar references for 1.2.7.8
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Siddiqui MA, Fujiwara S, Imanaka T (1997). "Indolepyruvate ferredoxin oxidoreductase from Pyrococcus sp. KOD1 possesses a mosaic structure showing features of various oxidoreductases". Mol. Gen. Genet. 254: 433–9. doi:10.1007/PL00008607. PMID 9180697.
Tersteegen A, Linder D, Thauer RK, Hedderich R (1997). "Structures and functions of four anabolic 2-oxoacid oxidoreductases in Methanobacterium thermoautotrophicum". Eur. J. Biochem. 244: 862–8. doi:10.1111/j.1432-1033.1997.00862.x. PMID 9108258.
Schut GJ, Menon AL, Adams MW (2001). "2-keto acid oxidoreductases from Pyrococcus furiosus and Thermococcus litoralis". Methods. Enzymol. 331: 144–58. PMID 11265457.