Indolepyruvate C-methyltransferase
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In enzymology, an indolepyruvate C-methyltransferase (EC 2.1.1.47) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + (indol-3-yl)pyruvate
S-adenosyl-L-homocysteine + (3S)-3-(indol-3-yl)-3-oxobutanoate
Thus, the two substrates of this enzyme are S-adenosyl methionine and (indol-3-yl)pyruvate, whereas its two products are S-adenosylhomocysteine and (3S)-3-(indol-3-yl)-3-oxobutanoate.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine: (indol-3-yl)pyruvate C-methyltransferase. Other names in common use include indolepyruvate methyltransferase, indolepyruvate 3-methyltransferase, indolepyruvic acid methyltransferase, and S-adenosyl-L-methionine:indolepyruvate C-methyltransferase. This enzyme participates in tryptophan metabolism.
[edit] References
- IUBMB entry for 2.1.1.47
- BRENDA references for 2.1.1.47 (Recommended.)
- PubMed references for 2.1.1.47
- PubMed Central references for 2.1.1.47
- Google Scholar references for 2.1.1.47
- Hornemann U, Speedie MK, Hurley LH, Floss HG (1970). "Demonstration of a C-methylating enzyme in cell free extracts of indolmycin-producing Streptomyces griseus". Biochem. Biophys. Res. Commun. 39: 594–9. doi:. PMID 5490210.
[edit] External links
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- The CAS registry number for this enzyme class is 54576-88-4.
[edit] Gene Ontology (GO) codes
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