INADL

From Wikipedia, the free encyclopedia

InaD-like (Drosophila)

PDB rendering based on 2d92.

Available structures: 2d92, 2daz, 2db5, 2dlu, 2dm8, 2dmz

Identifiers

Symbol(s)

INADL; Cipp; FLJ26982; PATJ

External IDs

OMIM: 603199 MGI: 1277960 HomoloGene: 72199

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• cellular_component • tight junction • membrane • apical part of cell
Biological Process:	• intracellular signaling cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005799 (mRNA)
NP_005790 (protein)

NM_001005784 (mRNA)
NP_001005784 (protein)

Location

Chr 1: 61.98 - 62.4 Mb

Chr 4: 97.89 - 98.21 Mb

Pubmed search

[1]

[2]

InaD-like (Drosophila), also known as INADL, is a human gene.^[1]

This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors.^[1]

[edit] References

^ ^a ^b Entrez Gene: INADL InaD-like (Drosophila).

[edit] Further reading

Fanning AS, Anderson JM (1999). "PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane.". J. Clin. Invest. 103 (6): 767–72. PMID 10079096.
Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996). "The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression.". Genomics 33 (1): 151–2. doi:10.1006/geno.1996.0177. PMID 8617505.
Philipp S, Flockerzi V (1997). "Molecular characterization of a novel human PDZ domain protein with homology to INAD from Drosophila melanogaster.". FEBS Lett. 413 (2): 243–8. PMID 9280290.
Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ (1998). "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins.". Mol. Cell. Neurosci. 11 (3): 161–72. doi:10.1006/mcne.1998.0679. PMID 9647694.
Soejima H, Kawamoto S, Akai J, et al. (2001). "Isolation of novel heart-specific genes using the BodyMap database.". Genomics 74 (1): 115–20. doi:10.1006/geno.2001.6527. PMID 11374908.
Vaccaro P, Brannetti B, Montecchi-Palazzi L, et al. (2001). "Distinct binding specificity of the multiple PDZ domains of INADL, a human protein with homology to INAD from Drosophila melanogaster.". J. Biol. Chem. 276 (45): 42122–30. doi:10.1074/jbc.M104208200. PMID 11509564.
Anzai N, Deval E, Schaefer L, et al. (2002). "The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons.". J. Biol. Chem. 277 (19): 16655–61. doi:10.1074/jbc.M201087200. PMID 11872753.
Roh MH, Makarova O, Liu CJ, et al. (2002). "The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost.". J. Cell Biol. 157 (1): 161–72. doi:10.1083/jcb.200109010. PMID 11927608.
Lemmers C, Médina E, Delgrossi MH, et al. (2002). "hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells.". J. Biol. Chem. 277 (28): 25408–15. doi:10.1074/jbc.M202196200. PMID 11964389.
Roh MH, Liu CJ, Laurinec S, Margolis B (2002). "The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions.". J. Biol. Chem. 277 (30): 27501–9. doi:10.1074/jbc.M201177200. PMID 12021270.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Makarova O, Roh MH, Liu CJ, et al. (2003). "Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1).". Gene 302 (1-2): 21–9. PMID 12527193.
Roh MH, Fan S, Liu CJ, Margolis B (2004). "The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells.". J. Cell. Sci. 116 (Pt 14): 2895–906. doi:10.1242/jcs.00500. PMID 12771187.
Li Y, Karnak D, Demeler B, et al. (2005). "Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes.". EMBO J. 23 (14): 2723–33. doi:10.1038/sj.emboj.7600294. PMID 15241471.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Michel D, Arsanto JP, Massey-Harroche D, et al. (2005). "PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells.". J. Cell. Sci. 118 (Pt 17): 4049–57. doi:10.1242/jcs.02528. PMID 16129888.
Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G (2007). "Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays.". J. Am. Chem. Soc. 128 (17): 5913–22. doi:10.1021/ja060943h. PMID 16637659.
Wells CD, Fawcett JP, Traweger A, et al. (2006). "A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells.". Cell 125 (3): 535–48. doi:10.1016/j.cell.2006.02.045. PMID 16678097.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.