IMPA1

From Wikipedia, the free encyclopedia

Inositol(myo)-1(or 4)-monophosphatase 1

PDB rendering based on 1awb.

Available structures: 1awb, 1ima, 1imb, 1imc, 1imd, 1ime, 1imf, 2hhm

Identifiers

Symbol(s)

IMPA1; IMPA

External IDs

OMIM: 602064 MGI: 1933158 HomoloGene: 4043

Gene ontology
Molecular Function:	• magnesium ion binding • inositol-1(or 4)-monophosphatase activity • hydrolase activity • lithium ion binding • phosphoric ester hydrolase activity
Biological Process:	• carbohydrate metabolic process • phosphatidylinositol biosynthetic process • phosphate metabolic process • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005536 (mRNA)
NP_005527 (protein)

NM_018864 (mRNA)
NP_061352 (protein)

Location

Chr 8: 82.73 - 82.76 Mb

Chr 3: 10.3 - 10.31 Mb

Pubmed search

[1]

[2]

Inositol(myo)-1(or 4)-monophosphatase 1, also known as IMPA1, is a human gene.^[1]

[edit] References

^ Entrez Gene: IMPA1 inositol(myo)-1(or 4)-monophosphatase 1.

[edit] Further reading

Bone R, Springer JP, Atack JR (1992). "Structure of inositol monophosphatase, the putative target of lithium therapy.". Proc. Natl. Acad. Sci. U.S.A. 89 (21): 10031-5. PMID 1332026.
McAllister G, Whiting P, Hammond EA, et al. (1992). "cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme.". Biochem. J. 284 ( Pt 3): 749-54. PMID 1377913.
Hallcher LM, Sherman WR (1981). "The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.". J. Biol. Chem. 255 (22): 10896-901. PMID 6253491.
Bone R, Frank L, Springer JP, et al. (1994). "Structural analysis of inositol monophosphatase complexes with substrates.". Biochemistry 33 (32): 9460-7. PMID 8068620.
Bone R, Frank L, Springer JP, Atack JR (1994). "Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion catalysis.". Biochemistry 33 (32): 9468-76. PMID 8068621.
Ganzhorn AJ, Lepage P, Pelton PD, et al. (1996). "The contribution of lysine-36 to catalysis by human myo-inositol monophosphatase.". Biochemistry 35 (33): 10957-66. doi:10.1021/bi9603837. PMID 8718889.
Parthasarathy L, Parthasarathy R, Vadnal R (1997). "Molecular characterization of coding and untranslated regions of rat cortex lithium-sensitive myo-inositol monophosphatase cDNA.". Gene 191 (1): 81-7. PMID 9210592.
Sjøholt G, Molven A, Løvlie R, et al. (1997). "Genomic structure and chromosomal localization of a human myo-inositol monophosphatase gene (IMPA).". Genomics 45 (1): 113-22. doi:10.1006/geno.1997.4862. PMID 9339367.
Nemanov L, Ebstein RP, Belmaker RH, et al.. "Effect of bipolar disorder on lymphocyte inositol monophosphatase mRNA levels." 2 (1): 25-29. doi:10.1017/S1461145799001315. PMID 11281967.
Bahn JH, Kim AY, Jang SH, et al. (2002). "Production of monoclonal antibodies and immunohistochemical studies of brain myo-inositol monophosphate phosphatase.". Mol. Cells 13 (1): 21-7. PMID 11911470.
Atack JR, Schapiro MB (2002). "Inositol monophosphatase activity in normal, Down syndrome and dementia of the Alzheimer type CSF.". Neurobiol. Aging 23 (3): 389-96. PMID 11959401.
Berggard T, Szczepankiewicz O, Thulin E, Linse S (2003). "Myo-inositol monophosphatase is an activated target of calbindin D28k.". J. Biol. Chem. 277 (44): 41954-9. doi:10.1074/jbc.M203492200. PMID 12176979.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sjøholt G, Ebstein RP, Lie RT, et al. (2005). "Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder.". Mol. Psychiatry 9 (6): 621-9. doi:10.1038/sj.mp.4001460. PMID 14699425.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Ohnishi T, Ohba H, Seo KC, et al. (2007). "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1.". J. Biol. Chem. 282 (1): 637-46. doi:10.1074/jbc.M604474200. PMID 17068342.