IL31RA

From Wikipedia, the free encyclopedia

Interleukin 31 receptor A

Identifiers

IL31RA; CRL; CRL3; GLM-R; GLMR; GPL; IL-31RA; MGC125346; PRO21384

External IDs

OMIM: 609510 MGI: 2180511 HomoloGene: 51395

Gene ontology
Molecular Function:	• transcription coactivator activity • receptor activity • hematopoietin/interferon-class (D200-domain) cytokine receptor activity • protein kinase binding • cytokine binding
Cellular Component:	• integral to membrane
Biological Process:	• MAPKKK cascade • anti-apoptosis • defense response • transmembrane receptor protein tyrosine kinase signaling pathway • JAK-STAT cascade • positive regulation of cell proliferation • cytokine and chemokine mediated signaling pathway • monocyte differentiation • macrophage differentiation • positive regulation of tyrosine phosphorylation of Stat3 protein • positive regulation of tyrosine phosphorylation of Stat5 protein • homeostatic process • negative regulation of macrophage activation • positive regulation of transcription, DNA-dependent

Orthologs

Human

Mouse

Refseq

NM_139017 (mRNA)
NP_620586 (protein)

NM_139299 (mRNA)
NP_647460 (protein)

Location

Chr 5: 55.18 - 55.25 Mb

Chr 13: 113.64 - 113.7 Mb

Pubmed search

[1]

[2]

Interleukin 31 receptor A, also known as IL31RA, is a human gene.^[1]

IL31RA is related to gp130 (IL6ST; MIM 600694), the common receptor subunit for IL6 (MIM 147620)-type cytokines. Oncostatin M receptor (OSMR; MIM 601743) and IL31RA form the heterodimeric receptor through which IL31 (MIM 609509) signals. Expression of IL31RA and OSMR mRNA is induced in activated monocytes, and both mRNAs are constitutively expressed in epithelial cells (Dillon et al., 2004).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: IL31RA interleukin 31 receptor A.

[edit] Further reading

Ghilardi N, Li J, Hongo JA, et al. (2002). "A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5.". J. Biol. Chem. 277 (19): 16831–6. doi:10.1074/jbc.M201140200. PMID 11877449.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Diveu C, Lelièvre E, Perret D, et al. (2004). "GPL, a novel cytokine receptor related to GP130 and leukemia inhibitory factor receptor.". J. Biol. Chem. 278 (50): 49850–9. doi:10.1074/jbc.M307286200. PMID 14504285.
Dillon SR, Sprecher C, Hammond A, et al. (2004). "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice.". Nat. Immunol. 5 (7): 752–60. doi:10.1038/ni1084. PMID 15184896.
Dreuw A, Radtke S, Pflanz S, et al. (2005). "Characterization of the signaling capacities of the novel gp130-like cytokine receptor.". J. Biol. Chem. 279 (34): 36112–20. doi:10.1074/jbc.M401122200. PMID 15194700.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Diveu C, Lak-Hal AH, Froger J, et al. (2005). "Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling.". Eur. Cytokine Netw. 15 (4): 291–302. PMID 15627637.
Bilsborough J, Leung DY, Maurer M, et al. (2006). "IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis.". J. Allergy Clin. Immunol. 117 (2): 418–25. doi:10.1016/j.jaci.2005.10.046. PMID 16461143.