IL1RL2

From Wikipedia, the free encyclopedia

Interleukin 1 receptor-like 2

Identifiers

IL1RL2; IL1R-rp2; IL1RRP2

External IDs

OMIM: 604512 MGI: 1913107 HomoloGene: 2860

Gene ontology
Molecular Function:	• transmembrane receptor activity • interleukin-1, Type I, activating receptor activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• cellular defense response • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003854 (mRNA)
NP_003845 (protein)

NM_133193 (mRNA)
NP_573456 (protein)

Location

Chr 2: 102.17 - 102.22 Mb

Chr 1: 40.27 - 40.31 Mb

Pubmed search

[1]

[2]

Interleukin 1 receptor-like 2, also known as IL1RL2, is a human gene.^[1]

The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.^[1]

[edit] References

^ ^a ^b Entrez Gene: IL1RL2 interleukin 1 receptor-like 2.

[edit] Further reading

McMahan CJ, Slack JL, Mosley B, et al. (1991). "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.". EMBO J. 10 (10): 2821–32. PMID 1833184.
Colotta F, Re F, Muzio M, et al. (1993). "Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4.". Science 261 (5120): 472–5. PMID 8332913.
Lovenberg TW, Crowe PD, Liu C, et al. (1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2).". J. Neuroimmunol. 70 (2): 113–22. PMID 8898719.
Torigoe K, Ushio S, Okura T, et al. (1997). "Purification and characterization of the human interleukin-18 receptor.". J. Biol. Chem. 272 (41): 25737–42. PMID 9325300.
Dale M, Nicklin MJ (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.". Genomics 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101.
Born TL, Smith DE, Garka KE, et al. (2000). "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling.". J. Biol. Chem. 275 (39): 29946–54. doi:10.1074/jbc.M004077200. PMID 10882729.
Debets R, Timans JC, Homey B, et al. (2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2.". J. Immunol. 167 (3): 1440–6. PMID 11466363.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ozkara C, Uzan M, Tanriverdi T, et al. (2006). "Lack of association between IL-1beta/alpha gene polymorphisms and temporal lobe epilepsy with hippocampal sclerosis.". Seizure : the journal of the British Epilepsy Association 15 (5): 288–91. doi:10.1016/j.seizure.2006.02.016. PMID 16546408.