IL1RL1

From Wikipedia, the free encyclopedia

Interleukin 1 receptor-like 1

Identifiers

IL1RL1; T1; ST2; DER4; FIT-1; MGC32623; ST2L; ST2V

External IDs

OMIM: 601203 MGI: 98427 HomoloGene: 2862

Gene ontology
Molecular Function:	• transmembrane receptor activity • interleukin-1 receptor activity • receptor signaling protein activity • protein binding
Cellular Component:	• cellular_component • membrane • integral to membrane
Biological Process:	• immune response • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003856 (mRNA)
NP_003847 (protein)

NM_001025602 (mRNA)
NP_001020773 (protein)

Location

Chr 2: 102.29 - 102.33 Mb

Chr 1: 40.37 - 40.41 Mb

Pubmed search

[1]

[2]

Interleukin 1 receptor-like 1, also known as IL1RL1, is a human gene.^[1]

The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants.^[1]

[edit] References

^ ^a ^b Entrez Gene: IL1RL1 interleukin 1 receptor-like 1.

[edit] Further reading

Tominaga S, Yokota T, Yanagisawa K, et al. (1993). "Nucleotide sequence of a complementary DNA for human ST2.". Biochim. Biophys. Acta 1171 (2): 215–8. PMID 1482686.
Gayle MA, Slack JL, Bonnert TP, et al. (1996). "Cloning of a putative ligand for the T1/ST2 receptor.". J. Biol. Chem. 271 (10): 5784–9. PMID 8621446.
Yanagisawa K, Naito Y, Kuroiwa K, et al. (1997). "The expression of ST2 gene in helper T cells and the binding of ST2 protein to myeloma-derived RPMI8226 cells.". J. Biochem. 121 (1): 95–103. PMID 9058198.
Kumar S, Tzimas MN, Griswold DE, Young PR (1997). "Expression of ST2, an interleukin-1 receptor homologue, is induced by proinflammatory stimuli.". Biochem. Biophys. Res. Commun. 235 (3): 474–8. doi:10.1006/bbrc.1997.6810. PMID 9207179.
Löhning M, Stroehmann A, Coyle AJ, et al. (1998). "T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function.". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6930–5. PMID 9618516.
Moritz DR, Rodewald HR, Gheyselinck J, Klemenz R (1998). "The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitors.". J. Immunol. 161 (9): 4866–74. PMID 9794420.
Saccani S, Polentarutti N, Penton-Rol G, et al. (1999). "Divergent effects of LPS on expression of IL-1 receptor family members in mononuclear phagocytes in vitro and in vivo.". Cytokine 10 (10): 773–80. doi:10.1006/cyto.1998.0359. PMID 9811530.
Dale M, Nicklin MJ (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.". Genomics 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101.
Iwahana H, Yanagisawa K, Ito-Kosaka A, et al. (1999). "Different promoter usage and multiple transcription initiation sites of the interleukin-1 receptor-related human ST2 gene in UT-7 and TM12 cells.". Eur. J. Biochem. 264 (2): 397–406. PMID 10491084.
Tominaga S, Kuroiwa K, Tago K, et al. (1999). "Presence and expression of a novel variant form of ST2 gene product in human leukemic cell line UT-7/GM.". Biochem. Biophys. Res. Commun. 264 (1): 14–8. doi:10.1006/bbrc.1999.1469. PMID 10527832.
Li H, Tago K, Io K, et al. (2000). "The cloning and nucleotide sequence of human ST2L cDNA.". Genomics 67 (3): 284–90. doi:10.1006/geno.2000.6269. PMID 10936050.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Sweet MJ, Leung BP, Kang D, et al. (2001). "A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression.". J. Immunol. 166 (11): 6633–9. PMID 11359817.
Tago K, Noda T, Hayakawa M, et al. (2001). "Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V.". Biochem. Biophys. Res. Commun. 285 (5): 1377–83. doi:10.1006/bbrc.2001.5306. PMID 11478810.
Lécart S, Lecointe N, Subramaniam A, et al. (2002). "Activated, but not resting human Th2 cells, in contrast to Th1 and T regulatory cells, produce soluble ST2 and express low levels of ST2L at the cell surface.". Eur. J. Immunol. 32 (10): 2979–87. doi:10.1002/1521-4141(2002010)32:10<2979::AID-IMMU2979>3.0.CO;2-5. PMID 12355452.
Brint EK, Fitzgerald KA, Smith P, et al. (2003). "Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction.". J. Biol. Chem. 277 (51): 49205–11. doi:10.1074/jbc.M209685200. PMID 12368275.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Haga Y, Yanagisawa K, Ohto-Ozaki H, et al. (2003). "The effect of ST2 gene product on anchorage-independent growth of a glioblastoma cell line, T98G.". Eur. J. Biochem. 270 (1): 163–70. PMID 12492487.
Weinberg EO, Shimpo M, Hurwitz S, et al. (2003). "Identification of serum soluble ST2 receptor as a novel heart failure biomarker.". Circulation 107 (5): 721–6. PMID 12578875.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.