IL1RAP

From Wikipedia, the free encyclopedia

Interleukin 1 receptor accessory protein

Identifiers

IL1RAP; FLJ37788; IL-1RAcP; IL1R3

External IDs

OMIM: 602626 MGI: 104975 HomoloGene: 1643

Gene ontology
Molecular Function:	• transmembrane receptor activity • interleukin-1 receptor activity • protein binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• protein complex assembly • inflammatory response • immune response • cytokine and chemokine mediated signaling pathway • interleukin-2 biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002182 (mRNA)
NP_002173 (protein)

NM_008364 (mRNA)
NP_032390 (protein)

Location

Chr 3: 191.71 - 191.86 Mb

Chr 16: 26.5 - 26.64 Mb

Pubmed search

[1]

[2]

Interleukin 1 receptor accessory protein, also known as IL1RAP, is a human gene.^[1]

Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble.^[1]

[edit] References

^ ^a ^b Entrez Gene: IL1RAP interleukin 1 receptor accessory protein.

[edit] Further reading

Greenfeder SA, Nunes P, Kwee L, et al. (1995). "Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex.". J. Biol. Chem. 270 (23): 13757-65. PMID 7775431.
Parnet P, Garka KE, Bonnert TP, et al. (1996). "IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP.". J. Biol. Chem. 271 (8): 3967-70. PMID 8626725.
Wesche H, Korherr C, Kracht M, et al. (1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases).". J. Biol. Chem. 272 (12): 7727-31. PMID 9065432.
Huang J, Gao X, Li S, Cao Z (1998). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein.". Proc. Natl. Acad. Sci. U.S.A. 94 (24): 12829-32. PMID 9371760.
Dale M, Hammond DW, Cox A, Nicklin MJ (1998). "The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping.". Genomics 47 (2): 325-6. doi:10.1006/geno.1997.5113. PMID 9479509.
Cullinan EB, Kwee L, Nunes P, et al. (1998). "IL-1 receptor accessory protein is an essential component of the IL-1 receptor.". J. Immunol. 161 (10): 5614-20. PMID 9820540.
Lang D, Knop J, Wesche H, et al. (1999). "The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness.". J. Immunol. 161 (12): 6871-7. PMID 9862719.
Morton NM, de Groot RP, Cawthorne MA, Emilsson V (1999). "Interleukin-1beta activates a short STAT-3 isoform in clonal insulin-secreting cells.". FEBS Lett. 442 (1): 57-60. PMID 9923604.
Sizemore N, Leung S, Stark GR (1999). "Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit.". Mol. Cell. Biol. 19 (7): 4798-805. PMID 10373529.
Jensen LE, Muzio M, Mantovani A, Whitehead AS (2000). "IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein.". J. Immunol. 164 (10): 5277-86. PMID 10799889.
Burns K, Clatworthy J, Martin L, et al. (2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.". Nat. Cell Biol. 2 (6): 346-51. doi:10.1038/35014038. PMID 10854325.
Bigonnesse F, Marois M, Maheux R, Akoum A (2001). "Interleukin-1 receptor accessory protein is constitutively expressed in human endometrium throughout the menstrual cycle.". Mol. Hum. Reprod. 7 (4): 333-9. PMID 11279295.
Jefferies C, Bowie A, Brady G, et al. (2001). "Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1.". Mol. Cell. Biol. 21 (14): 4544-52. doi:10.1128/MCB.21.14.4544-4552.2001. PMID 11416133.
Radons J, Gabler S, Wesche H, et al. (2002). "Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling.". J. Biol. Chem. 277 (19): 16456-63. doi:10.1074/jbc.M201000200. PMID 11880380.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ruhul Amin AR, Machida K, Oshima K, et al. (2003). "A role for SHPS-1/SIRPalpha1 in IL-1beta- and TNFalpha-dependent signaling.". Oncogene 21 (57): 8871-8. doi:10.1038/sj.onc.1206018. PMID 12483539.
Smith DE, Hanna R, Della Friend, et al. (2003). "The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action.". Immunity 18 (1): 87-96. PMID 12530978.
Boch JA, Yoshida Y, Koyama Y, et al. (2003). "Characterization of a cascade of protein interactions initiated at the IL-1 receptor.". Biochem. Biophys. Res. Commun. 303 (2): 525-31. PMID 12659850.
Bin LH, Xu LG, Shu HB (2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling.". J. Biol. Chem. 278 (27): 24526-32. doi:10.1074/jbc.M303451200. PMID 12721283.
Jensen LE, Whitehead AS (2004). "Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis.". Cell. Signal. 15 (8): 793-802. PMID 12781872.