IL1F10

From Wikipedia, the free encyclopedia

Interleukin 1 family, member 10 (theta)

Identifiers

IL1F10; FIL1-theta; FKSG75; IL-1HY2; IL1-theta; MGC119831; MGC119832; MGC119833

External IDs

Gene ontology
Molecular Function:	• interleukin-1 receptor antagonist activity
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• inflammatory response • immune response

Orthologs

Human

Mouse

Refseq

NM_032556 (mRNA)
NP_115945 (protein)

NM_153077 (mRNA)
NP_694717 (protein)

Location

Chr 2: 113.54 - 113.55 Mb

Chr 2: 24.11 - 24.12 Mb

Pubmed search

[1]

[2]

Interleukin 1 family, member 10 (theta), also known as IL1F10, is a human gene.^[1]

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported.^[1]

[edit] References

^ ^a ^b Entrez Gene: IL1F10 interleukin 1 family, member 10 (theta).

[edit] Further reading

Nicklin MJ, Weith A, Duff GW (1994). "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes.". Genomics 19 (2): 382–4. doi:10.1006/geno.1994.1076. PMID 8188271.
Nothwang HG, Strahm B, Denich D, et al. (1997). "Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13.". Genomics 41 (3): 370–8. doi:10.1006/geno.1997.4654. PMID 9169134.
Mulero JJ, Pace AM, Nelken ST, et al. (1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene.". Biochem. Biophys. Res. Commun. 263 (3): 702–6. doi:10.1006/bbrc.1999.1440. PMID 10512743.
Smith DE, Renshaw BR, Ketchem RR, et al. (2000). "Four new members expand the interleukin-1 superfamily.". J. Biol. Chem. 275 (2): 1169–75. PMID 10625660.
Kumar S, McDonnell PC, Lehr R, et al. (2000). "Identification and initial characterization of four novel members of the interleukin-1 family.". J. Biol. Chem. 275 (14): 10308–14. PMID 10744718.
Busfield SJ, Comrack CA, Yu G, et al. (2000). "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2.". Genomics 66 (2): 213–6. doi:10.1006/geno.2000.6184. PMID 10860666.
Barton JL, Herbst R, Bosisio D, et al. (2001). "A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities.". Eur. J. Immunol. 30 (11): 3299–308. PMID 11093146.
Pan G, Risser P, Mao W, et al. (2001). "IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp.". Cytokine 13 (1): 1–7. doi:10.1006/cyto.2000.0799. PMID 11145836.
Lin H, Ho AS, Haley-Vicente D, et al. (2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member.". J. Biol. Chem. 276 (23): 20597–602. doi:10.1074/jbc.M010095200. PMID 11278614.
Debets R, Timans JC, Homey B, et al. (2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2.". J. Immunol. 167 (3): 1440–6. PMID 11466363.
Sims JE, Nicklin MJ, Bazan JF, et al. (2001). "A new nomenclature for IL-1-family genes.". Trends Immunol. 22 (10): 536–7. PMID 11574262.
Bensen JT, Dawson PA, Mychaleckyj JC, Bowden DW (2002). "Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14.". J. Interferon Cytokine Res. 21 (11): 899–904. doi:10.1089/107999001753289505. PMID 11747621.
Nicklin MJ, Barton JL, Nguyen M, et al. (2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster.". Genomics 79 (5): 718–25. doi:10.1006/geno.2002.6751. PMID 11991722.
Taylor SL, Renshaw BR, Garka KE, et al. (2002). "Genomic organization of the interleukin-1 locus.". Genomics 79 (5): 726–33. doi:10.1006/geno.2002.6752. PMID 11991723.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.