IKZF4

From Wikipedia, the free encyclopedia

IKAROS family zinc finger 4 (Eos)

Identifiers

IKZF4; EOS; KIAA1782; ZNFN1A4

External IDs

OMIM: 606239 MGI: 1343139 HomoloGene: 69103

Gene ontology
Molecular Function:	• nucleic acid binding • transcription factor activity • zinc ion binding • transcription repressor activity • metal ion binding
Cellular Component:	• intracellular • nucleus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_022465 (mRNA)
NP_071910 (protein)

XM_978666 (mRNA)
XP_983760 (protein)

Location

Chr 12: 54.7 - 54.72 Mb

Chr 10: 128.04 - 128.05 Mb

Pubmed search

[1]

[2]

IKAROS family zinc finger 4 (Eos), also known as IKZF4, is a human gene.^[1]

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: IKZF4 IKAROS family zinc finger 4 (Eos).

[edit] Further reading

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Bao J, Lin H, Ouyang Y, et al. (2005). "Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos.". Nat. Neurosci. 7 (11): 1250-8. doi:10.1038/nn1342. PMID 15494726.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Perdomo J, Crossley M (2003). "The Ikaros family protein Eos associates with C-terminal-binding protein corepressors.". Eur. J. Biochem. 269 (23): 5885-92. PMID 12444977.
Koipally J, Georgopoulos K (2002). "A molecular dissection of the repression circuitry of Ikaros.". J. Biol. Chem. 277 (31): 27697-705. doi:10.1074/jbc.M201694200. PMID 12015313.
Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 8 (2): 85-95. PMID 11347906.
Perdomo J, Holmes M, Chong B, Crossley M (2001). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities.". J. Biol. Chem. 275 (49): 38347-54. doi:10.1074/jbc.M005457200. PMID 10978333.
Honma Y, Kiyosawa H, Mori T, et al. (1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system.". FEBS Lett. 447 (1): 76-80. PMID 10218586.