IHPK2

From Wikipedia, the free encyclopedia

Inositol hexaphosphate kinase 2

Identifiers

IHPK2; PiUS; IP6K2

External IDs

OMIM: 606992 MGI: 1923750 HomoloGene: 56929

Gene ontology
Molecular Function:	• inositol trisphosphate 3-kinase activity • polyphosphate kinase activity • transferase activity • inositol hexakisphosphate kinase activity
Cellular Component:	• nucleus
Biological Process:	• negative regulation of cell growth • positive regulation of apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001005912 (mRNA)
NP_001005912 (protein)

XM_977756 (mRNA)
XP_982850 (protein)

Location

Chr 3: 48.7 - 48.73 Mb

Chr 9: 108.64 - 108.66 Mb

Pubmed search

[1]

[2]

Inositol hexaphosphate kinase 2, also known as IHPK2, is a human gene.^[1]

This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: IHPK2 inositol hexaphosphate kinase 2.

[edit] Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
White KE, Econs MJ (1998). "Localization of PiUS, a stimulator of cellular phosphate uptake to human chromosome 3p21.3.". Somat. Cell Mol. Genet. 24 (1): 71–4. PMID 9776982.
Saiardi A, Erdjument-Bromage H, Snowman AM, et al. (2000). "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases.". Curr. Biol. 9 (22): 1323–6. PMID 10574768.
Saiardi A, Caffrey JJ, Snyder SH, Shears SB (2000). "The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis.". J. Biol. Chem. 275 (32): 24686–92. doi:10.1074/jbc.M002750200. PMID 10827188.
Morrison BH, Bauer JA, Kalvakolanu DV, Lindner DJ (2001). "Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells.". J. Biol. Chem. 276 (27): 24965–70. doi:10.1074/jbc.M101161200. PMID 11337497.
Saiardi A, Nagata E, Luo HR, et al. (2001). "Identification and characterization of a novel inositol hexakisphosphate kinase.". J. Biol. Chem. 276 (42): 39179–85. doi:10.1074/jbc.M106842200. PMID 11502751.
Morrison BH, Bauer JA, Hu J, et al. (2002). "Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics.". Oncogene 21 (12): 1882–9. doi:10.1038/sj.onc.1205265. PMID 11896621.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Nagata E, Luo HR, Saiardi A, et al. (2005). "Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death.". J. Biol. Chem. 280 (2): 1634–40. doi:10.1074/jbc.M409416200. PMID 15533939.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Morrison BH, Bauer JA, Lupica JA, et al. (2007). "Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation.". J. Biol. Chem. 282 (21): 15349–56. doi:10.1074/jbc.M700156200. PMID 17379600.